久坐行为与急性胰腺炎发病风险的关系:基于英国生物银行的队列研究  

Association between sedentary behavior and risk of acute pancreatitis:a cohort study based on the UK Biobank

作　　者：杨雨晴 董小武 路国涛[3] 潘佳佳 YANG Yuqing;DONG Xiaowu;LU Guotao;PAN Jiajia(School of Nursing and School of Public Health,Yangzhou University,Yangzhou 225009,China;不详)

机构地区：[1]扬州大学护理学院·公共卫生学院,江苏扬州225009 [2]扬州大学附属医院重症医学科,江苏扬州225001 [3]扬州大学附属医院消化内科,江苏扬州225001

出　　处：《山东医药》2025年第4期88-92,共5页Shandong Medical Journal

基　　金：国家自然科学基金青年科学基金项目(82200720);江苏省卫健委科研课题项目(Y12023039);江苏省卫生健康委医学科研面上项目(M2024105);扬州市政策引导类计划(国际科技合作)项目(YZ2022207);扬州市卫生健康委科研项目(2023-2-03)。

摘　　要：目的探讨久坐行为与急性胰腺炎(AP)发病风险的关系,为预防AP提供参考。方法基于英国生物银行数据纳入研究对象480716例,收集研究对象久坐行为时间作为暴露变量,研究对象年龄、性别、种族、教育水平等相关基线资料作为协变量。将久坐行为时间根据四分位间距分层为<3.0、3.0~<4.5、4.5~<6.0、≥6.0 h/d;比较不同水平久坐行为时间研究对象的基线资料。通过绘制Kaplan-Meier生存曲线分析不同水平久坐行为时间研究对象的AP累积发病率,采用限制性三次样条模型拟合Cox比例风险模型分析久坐行为时间与AP发病之间的关系,增量Cox比例风险模型分析久坐行为对AP发病风险的影响。结果480716例研究对象中,发生AP 2937例、未发生AP 477779例,AP发病率为0.61%。不同久坐行为时间分层的研究对象性别、年龄、种族、就业情况、教育水平等基线资料存在显著差异(P均<0.01)。Kaplan-Meier生存曲线显示,久坐行为时间越长,AP的累积发病率越高(P<0.01)。限制性三次样条回归模型拟合Cox比例风险模型分析结果显示,久坐时间与AP发病风险存在非线性关系(P=0.0167)。增量Cox回归模型分析结果显示,久坐行为时间与AP发病风险之间存在显著关联,且这种关联随着久坐行为时间的增加而增强。结论久坐行为时间延长与AP发病风险升高有关,并且具有阈值效应。Objective To investigate the association between sedentary behavior and the risk of acute pancreatitis(AP)and to provide references for AP prevention.Methods A cohort of 480,716 participants from the UK Biobank was included.Exposure variable(sedentary time)and covariates(age,sex,ethnicity,education level)were collected.Sedentary time was stratified by interquartile range into four groups:<3.0,3.0-<4.5,4.5-<6.0,and≥6.0 h/d.Base-line characteristics across groups were compared.Kaplan-Meier survival curves analyzed cumulative AP incidence.Re-stricted cubic spline models fitted Cox proportional hazards models to evaluate the nonlinear relationship between sedentary time and AP risk.Incremental Cox proportional hazards model was used to analyze the impact of sedentary behavior on the risk of acute pancreatitis.Results Among 480,716 participants,2,937 developed AP(incidence:0.61%).There were significant differences in the baseline information of gender,age,ethnicity,employment status,and education level of the study participants stratified by time of sedentary behaviour(all P<0.01).Kaplan-Meier curves demonstrated higher cumulative AP incidence with prolonged sedentary time(P<0.01).Restricted cubic spline analysis revealed a nonlinear relationship between sedentary time and AP risk(P=0.0167).Incremental Cox regression model confirmed a significant dose-response association,with risk intensifying as sedentary time increased.Conclusion Prolonged sedentary time is associated with an elevated risk of AP,exhibiting a threshold effect.

关 键 词：久坐行为 急性胰腺炎 发病风险 队列研究 英国生物银行 

分 类 号：R576[医药卫生—消化系统]