中性粒细胞与淋巴细胞比值与膀胱癌患者经尿道膀胱肿瘤电切术后复发的关系  

Relationship between neutrophil-to-lymphocyte ratio and the recurrence of bladder cancer patients after transurethral resection of bladder tumor

作　　者：王海才 应树森 陈峰 WANG Haicai;YING Shusen;CHEN Feng(Department of Urology,the Third People’s Hospital of Jingdezhen,Jingdezhen 333000,Jiangxi,China)

机构地区：[1]景德镇市第三人民医院泌尿外科,江西景德镇333000

出　　处：《癌症进展》2025年第8期946-949,共4页Oncology Progress

摘　　要：目的目的探讨中性粒细胞与淋巴细胞比值(NLR)与膀胱癌患者经尿道膀胱肿瘤电切术后复发的关系。方法选取50例膀胱癌患者,接受经尿道膀胱肿瘤电切术,记录术后6个月的复发情况,比较复发与未复发患者的临床特征。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估NLR对膀胱癌患者经尿道膀胱肿瘤电切术后复发的预测价值。以ROC曲线最佳截断值为分界,比较高NLR与低NLR患者的临床特征及复发情况。结果结果50例膀胱癌经尿道电切除术患者随访6个月,复发14例,未复发36例。复发与未复发膀胱癌经尿道电切除术患者临床分期、淋巴结转移情况、NLR比较,差异均有统计学意义(P﹤0.05)。ROC曲线显示,NLR预测膀胱癌患者经尿道电切术后复发的AUC为0.669(95%CI:0.545~0.735),最佳截断值为2.056。以NLR=2.056为界,高NLR与低NLR患者淋巴结转移情况和临床分期比较,差异均有统计学意义(P﹤0.05)。高NLR患者的复发率为45.45%,高于低NLR患者的14.29%,差异有统计学意义(P﹤0.05)。结论结论NLR与膀胱癌患者经尿道膀胱肿瘤电切术后复发密切相关,NLR可作为预测患者术后复发的指标,且高NLR患者更容易出现淋巴结转移,术后复发可能性更大。Objective To investigate the relationship between neutrophil-to-lymphocyte ratio(NLR)and the recur-rence of bladder cancer patients after transurethral resection of bladder tumor.Method Fifty patients with bladder cancer were selected and underwent transurethral resection of bladder tumor.The recurrence of patients 6 months after the opera-tion was recorded,and the clinical characteristics of patients with recurrence and without recurrence were compared.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the predic-tive value of NLR for recurrence of patients with bladder cancer after transurethral resection of bladder tumor was evalu-ated.Using the optimal cut-off value of the ROC curve as the boundary,the clinical characteristics and recurrence of pa-tients with high NLR and low NLR were compared.Result A total of 50 patients with bladder cancer were followed up for 6 months,14 cases were recurrent and 36 cases were non-recurrent.The clinical staging,lymph node metastasis and NLR of bladder cancer patients with and without recurrence after transurethral resection were significantly different(P<0.05).ROC curve showed that the AUC of NLR in predicting recurrence of patients with bladder cancer after transure-thral resection of bladder tumor was 0.669(95%CI:0.545-0.735),and the optimal cut-off value was 2.056.Using NLR=2.056 as the threshold,there were statistically significant differences in lymph node metastasis and clinical staging be-tween patients with high NLR and low NLR(P<0.05).The recurrence rate of high NLR patients was 45.45%,which was higher than 14.29%of low NLR patients,and the difference was statistically significant(P<0.05).Conclusion NLR is closely related to the recurrence of patients with bladder cancer after transurethral resection of bladder tumor.NLR can be used as an indicator for predicting postoperative recurrence,and patients with high NLR are more likely to have lymph node metastasis and more likely to have postoperative recurrence.

关 键 词：膀胱癌 经尿道膀胱肿瘤电切术 复发 淋巴结转移 临床分期 

分 类 号：R737.14[医药卫生—肿瘤]