基于“阳虚风动”理论治疗帕金森病异动症的临床研究  

Clinical study on the treatment of Parkinson's Disease Levodopa-induced Dyskinesia based on the theory of“the syndrome of stirring wind due to yang deficiency”

作　　者：邓颖[1] 吴雅文[1] 巫遥 DENG Ying;WU Yawen;WU Yao(Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,China)

机构地区：[1]江苏省中医院神经内科,江苏南京210029

出　　处：《内蒙古中医药》2025年第3期15-17,共3页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：目的:观察巴苁归芍颗粒治疗帕金森病异动症的临床疗效。方法:选取符合标准的帕金森病并发异动症患者64例,采用随机双盲对照,分为治疗组、对照组各32例,两组均常规服用多巴丝肼片,治疗组同时服用巴苁归芍颗粒,对照组同时服用金刚烷胺,每4周观察1次,观察8周。研究采用中医证候量表评分比较两组异动症的改善情况,帕金森病综合评分量表Ⅲ(UPDRSⅢ)、Ⅳ-A(UPDRSⅣ-A)。结果:治疗组治疗后中医证候评分、UPDRSⅢ、UPDRSⅣ-A均较治疗前明显降低(P<0.05),与对照组相比差异有统计学意义(P<0.05);治疗组总有效率为84.38%,对照组为62.5%,治疗组疗效明显优于对照组(P<0.05)。结论:巴苁归芍颗粒对改善帕金森病运动症状、异动等症状具有较好疗效。Objective:To observe the clinical efficacy of Bacongguishao granules in the treatment of Parkinson disease.Methods:64 pa-tients with Parkinson's disease complicated with dyskinesia meeting the criteria were selected and divided into treatment group(32 cases)and control group(32 cases)by random double-blind control.These two groups receive routine levodopa and benserazide tablet.The treat-ment group takes Bacongguishao granules,and the control group takes amantadine.The study compared the improvement of Levodopa-in-ducedyskinesia in the two groups by using TCM syndrome Scale(UPDRS-II)and Integrated score Scale IV-A(UPDRS IV-A).Results:TCM syndrome score,UPDRS II and UPDRS ivA in the treatment group were significantly lower after treatment than before treatment(P<0.05),and the difference was statistically significant compared with the control group(P<0.05).The total effective rate was 84.38%in the treatment group and 62.5%in the control group,and the curative effect of the treatment group was significantly better than that of the control group(P<0.05).Conclusion.Bacongguishao granules are ffective in improving motor symptoms and Levodopa-inducedyskinesia.

关 键 词：帕金森病 异动症 中医治疗 

分 类 号：R741[医药卫生—神经病学与精神病学]