Anticancer properties of beta-caryophyllene and d-limonene terpenes:A review  

作　　者：Ololade S.Gbadebo Elizabeth D.Oke Felix A.Ajibuwa 

机构地区：[1]Department of Biomedical and Pharmaceutical Sciences,University of Rhode Island,Kingston,Rhode Island,USA [2]College of Pharmacy and Pharmaceutical Sciences,Washington State University,Spokane,Washington,USA [3]Department of Pharmacology and Toxicology,American University of Beirut,Beirut,Lebanon

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2025年第4期129-140,共12页亚太热带生物医学杂志(英文版)

摘　　要：Terpenes are a structurally diverse family of secondary metabolites found mostly in plants and microorganisms.Beta-caryophyllene and d-limonene are abundant in aromatic medicinal plants.Beta-caryophyllene can be sourced from clove and cannabis amongst others,and d-limonene is abundant in the Citrus genera.Apart from their use in agriculture,cosmetics,and food industries,these terpenes possess a wide range of therapeutic activities,including antimicrobial,analgesic,and anticancer activities.This review discusses the anticancer effects of these two compounds against malignant tumors including breast,lung,gastrointestinal,bone,blood,endometrial,and bladder cancer.Beta-caryophyllene induces apoptosis and prevents proliferation and metastasis through the downregulation of HSP60,HTRA,survivin,XIAP,Bcl-xL,and Bcl-2 and the upregulation of caspase 3,annexin V,p21,Bad,Bak,and Bax.The anticancer activity is also mediated by G1/M arrest,ROS induction,and JAK1/STAT activation.d-Limonene exerts its anticancer effects by upregulating autophagy-linked genes,Bax,and caspase 3 and downregulating cyclin D1 and Bcl-2.These compounds also elicit synergistic effects upon co-administration with anticancer drugs and show great prospects as useful agents in the fight against cancer.

关 键 词：ANTICANCER Beta-caryophyllene D-LIMONENE TERPENES Drug discovery APOPTOSIS 

分 类 号：R285[医药卫生—中药学]