砷(胂)化合物在医学史上应用的研究现状  

Research status of arsenic(organoarsenic)compounds applied in medicine

作　　者：陆慧[1] 姚广泽 魏玉洁 王卉[1] 赵欣阳 朱森林 刘奕伶 杨乾磊 安艳[1] Lu Hui;Yao Guangze;Wei Yujie;Wang Hui;Zhao Xinyang;Zhu Senlin;Liu Yiling;Yang Qianlei;An Yan(Department of Toxicology,School of Public Heath,Medical College of Soochow University,Suzhou 215123,China;China-Japan Joint Laboratory on Environmental Health,School of Public Heath,Medical College of Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学苏州医学院公共卫生学院卫生毒理学系,苏州215123 [2]苏州大学苏州医学院公共卫生学院中日环境与健康联合实验室,苏州215123

出　　处：《中华地方病学杂志》2025年第3期253-258,共6页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81872646,81573173,81811540034,82381240027)。

摘　　要：砷(胂)化合物是人类治疗多种疾病的古老药物之一。从最初应用于治疗各类皮肤疾病,到20世纪70年代三氧化二砷(arsenic trioxide,ATO)被证实能够显著缓解急性早幼粒细胞白血病(acute promyelocytic leukemia,APL),砷(胂)化合物在医学发展史上逐渐占据了重要地位。本文回顾了无机砷化合物和有机胂化合物的药用研究进展,涵盖了抗癌、抗寄生虫、抗病毒和抗生素等方面,并进一步探讨了开发更高疗效和更低毒性的新的砷(胂)类药物的潜力,旨在为砷(胂)化合物在疾病治疗中的应用提供新的研究方向和思路。Arsenic(organoarsenic)compound is one of the oldest drugs used by humans to treat various diseases.From its initial application in treating various skin diseases to the 1970s when arsenic trioxide(ATO)was proven to be able to significantly relieve acute promyelocytic leukemia(APL),arsenic(organoarsenic)compounds gradually occupied an important position in the history of medical development.This article reviews the pharmaceutical research progress of inorganic arsenic compounds and organic arsine compounds,covering anticancer,antiparasitic,antiviral and antibiotic aspects.It further explores the potential for developing new arsenic(organoarsenic)drugs with higher efficacy and lower toxicity,aiming to provide new research directions and ideas for the application of arsenic(organoarsenic)compounds in disease treatment.

关 键 词：砷 三氧化二砷 医学用途 抗癌 抗病毒 抗生素 

分 类 号：R914[医药卫生—药物化学]