计算机认知矫正治疗结合抗精神病药物对老年器质性精神障碍的疗效研究  

Study on the Efficacy of CCRT Combined with Antipsychotic Drugs in the Treatment of Elderly Patients with Organic Mental Disorders

作　　者：张俊香 王文韬 赵玉鑫 ZHANG Junxiang;WANG Wentao;ZHAO Yuxin(Department of Psychiatry,Jiamusi Psychiatric Hospital,Jiamusi 154007,China)

机构地区：[1]佳木斯市精神病医院精神科,佳木斯154007

出　　处：《宁夏医科大学学报》2025年第3期267-271,共5页Journal of Ningxia Medical University

摘　　要：目的分析计算机认知矫正治疗(CCRT)结合抗精神病药物对老年器质性精神障碍患者预后的影响。方法回顾性分析150例老年器质性精神障碍患者的临床资料,给予利培酮治疗的患者为对照组(75例),结合CCRT治疗的为研究组(75例),比较两组患者疗效、阳性和阴性综合征量表(PANSS)评分、简明精神病评定量表评分(BPRS)、日常生活能力评分(ADL)、事件相关电位P300潜伏期、蒙特利尔认知评估量表(MoCA)评分。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后1、3个月,两组患者阳性、阴性症状及精神病理评分均随治疗时间延长而下降,且研究组均低于对照组(P均<0.05)。治疗后1、3个月,两组患者BPRS评分均随治疗时间延长而下降,ADL评分均随时间延长而升高,且研究组BPRS评分低于对照组,而ADL评分高于对照组(P均<0.05)。治疗后1、3个月,两组患者的Fz刺激点、Pz刺激点的潜伏期均随治疗时间延长而缩短,且研究组短于对照组(P均<0.05)。治疗后1、3个月两组患者MoCA评分均随治疗时间延长而升高,研究组高于对照组(P均<0.05)。结论CCRT结合抗精神病药物能够改善老年器质性精神障碍患者的病情,提高日常生活能力,改善预后,值得推广。Objective To analyze the effects of computerized cognitive correction therapy system(CCRT)combined with antipsychotic drugs on the prognosis of elderly patients with organic mental disorders.Methods Clinical data of 150 elderly patients with organic mental disorders were retrospectively analyzed,and were divided into control group and study group with 75 cases respectively according to treatment methods.The control group was treated with risperidone,and the study group was treated with CCRT.The efficacy,positive and negative syndrome scale(PANSS)score,brief psychiatric rating scale(BPRS)score,ability of daily living score(ADL),event-related potential P300 latency and montreal cognitive assessment scale(MoCA)score of the two groups were compared.Results The total effective rate of the study group was higher than that of the control group(P<0.05).At 1 and 3 months after treatment,the positive symptoms,negative symptoms and psychopathological scores of both groups decreased with the extension of time,and the study group was lower than the control group(P all<0.05).At 1 and 3 months after treatment,the BPRS score of both groups decreased with the extension of time,and the ADL score of both groups increased with the extension of time,and the BPRS score of the study group was lower than that of the control group,while the ADL score was higher than that of the control group(P all<0.05).At 1 and 3 months after treatment,the latency of Fz and Pz stimulation points in both groups decreased with the extension of time,and the study group was shorter than the control group(P all<0.05).At 1 and 3 months after treatment,the MoCA score of both groups increased with the extension of time,and the study group was higher than the control group(P all<0.05).Conclusion CCRT combined with antipsychotic drugs can improve the severity of the disease,improve the ability of daily living and improve the prognosis of the elderly patients with organic mental disorders,and it is worth promoting.

关 键 词：计算机认知矫正治疗 抗精神病药物 老年器质性精神障碍 

分 类 号：R749.3[医药卫生—神经病学与精神病学]