机构地区:[1]日照市疾病预防控制中心慢性病防制科,山东日照276800 [2]山东省疾病预防控制中心非传染性疾病防制所,山东济南250014
出 处:《中华肿瘤防治杂志》2025年第1期18-27,共10页Chinese Journal of Cancer Prevention and Treatment
摘 要:目的 分析山东省肿瘤登记地区2019年结直肠癌发病和死亡情况与2015-2019年间的变化趋势,为结直肠癌的预防控制提供参考依据。方法 收集2022年山东省35个肿瘤登记处提交的肿瘤登记数据,经过严格质量控制后对2015-2019年结直肠癌的发病率和死亡率及其标化率进行计算,并采用Joinpoint 4.8.0.1软件计算结直肠癌发病率和死亡率的年度变化百分比(APC)。结果 2019年山东省肿瘤登记地区结直肠癌发病率为33.83/10万,中标发病率为18.50/10万;结直肠癌死亡率为15.26/10万,中标死亡率为7.69/10万。男性和女性标化发病率分别为23.12/10万和14.14/10万,男性和女性标化死亡率分别为9.74/10万和5.82/10万。城市和农村标化发病率分别为20.56/10万和16.89/10万,城市和农村标化死亡率分别为8.64/10万和6.94/10万。直肠癌发病率和死亡率分别为18.68/10万和8.31/10万,高于结肠癌和肛门癌。年龄别发病率和年龄别死亡率均随着年龄的增长而增加,年龄别发病率在40岁以后快速上升,在80~84岁组到达最高峰;年龄别死亡率在45岁以后快速上升,在85~岁组到达最高峰。2015-2019年结直肠癌发病率、标化发病率、死亡率均呈总体上升趋势(APC分别为6.64%、4.52%和5.67%,P值分别为0.001、0.003和0.022),标化死亡率维持稳定状态(APC=2.90%,P=0.090)。结论 山东省结直肠癌发病率高于全国平均水平,且在2015-2019年呈上升趋势。结直肠癌筛查应重点关注男性和40岁以上人群。Objective To investigate the colorectal cancer incidence and mortality in Shangdong province in 2019 and trend change from 2015 to 2019, to provide reference for the prevention and control of colorectal cancer.Methods The data of 2015-2019 on colorectal cancer incidence and mortality among residents covered by 35 tumor registries across Shandong province were extracted from tumor registry system of the province. After data cleaning, annual crude and standardized(based on national population of China 2000 census) incidence and mortality rate of colorectal cancer among the residents were calculated. Joinpoint 4.8.0.1 software was used to estimate the annual percentage change(APC) in colorectal cancer incidence and mortality rate. Results The incidence rate of colorectal cancer in 2019 was 33.83/10~5, and the age-standardized incidence rate by Chinese standard population was 18.50/10~5. The mortality rate of colorectal cancer in 2019 was 15.26/10~5, and the age-standardized mortality rate by Chinese standard population was 7.69/10~5. Age-standardized incidence rate in males and females was 23.12/10~5 and 14.14/10~5, and age-standardized mortality rate in males and females was 9.74/10~5 and 5.82/10~5.Age-standardized incidence rate in urban and rural areas was 20.56/10~5 and 16.89/10~5,and age-standardized mortality rate in urban and rural areas was 9.74/10~5 and 5.82/10~5.Incidence and mortality rates of rectal cancer(18.68/10~5,8.31/10~5)were both higher than those of colon cancer and anal cancer.Both age-specific incidence and age-specific mortality increased with aging.The incidence and mortality of rectal cancer were higher than colon cancer and anal cancer.The incidence of colorectal cancer increased rapidly after the age of 40-years old,and reached the highest in the age group of 80-84years old.The mortality of colorectal cancer increased rapidly after the age of 45years old,and reached the highest in the age group of 85-years old.The crude and age-standardized incidence rate of colorectal cancer showed an ove
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