3-羟基-3-甲基戊二酰辅酶A还原酶调控机制的研究进展  

Progress in mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase

作　　者：陈星彤 杨金彪 周云越 杨帅虎 杨蕊红 方诗剑 马玉雪 牛雯颖[1] CHEN Xingtong;YANG Jinbiao;ZHOU Yunyue;YANG Shuaihu;YANG Ruihong;FANG Shijian;MA Yuxue;NIU Wenying

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150036

出　　处：《中国病理生理杂志》2025年第4期791-797,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82274405)。

摘　　要：胆固醇是人体重要的脂质,胆固醇水平过高可引发高胆固醇血症等疾病,3-羟基-3-甲基戊二酰辅酶A还原酶(3-hydroxy-3-methylglutaryl coenzyme A reductase,HMGCR)是催化胆固醇生物合成中的限速酶,因此HMGCR是调节胆固醇稳态的关键因素,HMGCR在体内的调控机制十分复杂。本文从HMGCR的转录表达、降解、活性方面总结了该酶调控机制的研究进展及与相关疾病的关系。Cholesterol is a crucial lipid in the human body.Elevated levels of cholesterol can result in conditions such as hypercholesterolemia.3-hydroxy-3-methylglutaryl coenzyme A reductase(HMGCR)serves as a pivotal enzyme in the synthesis of cholesterol,acting as a rate-limiting factor.As a result,HMGCR plays a critical role in maintaining cholesterol balance,with the regulatory processes being intricate in vivo.This review outlines the advancements in understanding the regulatory mechanisms of HMGCR,encompassing transcriptional control,degradation pathways,and enzyme activity.

关 键 词：3-羟基-3-甲基戊二酰辅酶A还原酶 高胆固醇血症 胆固醇 

分 类 号：R363.2[医药卫生—病理学] R393[医药卫生—基础医学] R589.2