星形胶质细胞和小胶质细胞及其相互作用对脊髓损伤影响的研究进展  

Research progress of astrocytes and microglia and their interactions in spinal cord injury

作　　者：程李 钟华璋 周云[1] CHENG Li;ZHONG Huazhang;ZHOU Yun(Department of Rehabilitation Medicine,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601)

机构地区：[1]安徽医科大学第二附属医院康复医学科,合肥230601

出　　处：《颈腰痛杂志》2025年第2期348-353,共6页The Journal of Cervicodynia and Lumbodynia

基　　金：安徽省重点研究和开发计划项目(人口健康领域)(201904a07020067);安徽省卫生健康科研项目(AHWJ2022b063);安徽医科大学第二附属医院国自然孵育计划项目(2022GMFY05)。

摘　　要：脊髓损伤(SCI)是一类主要由外伤及其他因素致脊髓受损,影响损伤节段以下的感觉及功能,严重降低患者的生活质量的疾患。在SCI的疾病进程中,星形胶质细胞及小胶质细胞相互影响,通过调控损伤后微环境的变化,共同参与SCI后的炎症、胶质瘢痕、神经性疼痛及髓鞘的再生修复,促进神经及机体功能的恢复。本文就星形胶质细胞及小胶质细胞相互作用在SCI后的作用展开综述,以期对SCI中二者的作用机制的有更深入的了解,并提供一些新的临床思路。Spinal cord injury(SCI)is primarily caused by trauma and other factors,leading to impaired sensation and function below the injury level,significantly reducing patients′quality of life.During SCI progression,astrocytes and microglia interact and jointly participate in processes such as inflammation,glial scar formation,neuropathic pain,and myelin regeneration and repair.By modulating the post-injury microenvironment,they contribute to the recovery of neural and bodily functions.This paper reviews the interactions between astrocytes and microglia following SCI,aiming to deepen the understanding of their mechanisms in SCI and offer new clinical insights.

关 键 词：星形胶质细胞 小胶质细胞 脊髓损伤 

分 类 号：R744[医药卫生—神经病学与精神病学]