白细胞介素-10家族抗肝纤维化的作用机制及临床应用价值  

The mechanism and clinical application value of interleukin-10 family in anti-hepatic fibrosis

作　　者：罗琪 曾碧雨 张荣 黄良江 付蕾[3] 姚春[1] LUO Qi;ZENG Biyu;ZHANG Rong;HUANG Liangjiang;FU Lei;YAO Chun(Graduate School of Guangxi University of Chinese Medicine,Nanning 530200,China;Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530200,China;Department of Science and Technology,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学研究生院,南宁530200 [2]广西中医药大学第一附属医院肝病科,南宁530200 [3]广西中医药大学科技部,南宁530200

出　　处：《临床肝胆病杂志》2025年第4期748-754,共7页Journal of Clinical Hepatology

基　　金：广西重点研发计划项目(桂科AB22035076);第七批全国老中医药专家学术经验继承工作项目(GZY2024002);2023年广西中医药多学科交叉创新团队(GZKJ2301);广西中医药大学“桂派中医药传承创新团队”A类资助项目(2022A001);广西中医药通阳散结法重点研究室项目;国家中医药管理局高水平中医药重点学科建设项目-中医内科学(zyyzdxk-2023166)。

摘　　要：白细胞介素-10(IL-10)家族在多种细胞中表达,具有广泛的生物学功能,在肝纤维化的发生发展中发挥重要作用。肝纤维化是一种慢性肝病,其特征是肝组织损伤后的异常修复、肝星状细胞活化及细胞外基质过度积累。IL-10家族成员包括IL-10、IL-19、IL-20、IL-22、IL-24、IL-26、IL-28、IL-29、IL-35等,在结构和功能上具有相似性,其表达水平的变化与肝纤维化的发展密切相关。适度上调IL-10家族成员表达可维持肝星状细胞静止状态,促进巨噬细胞向抗炎表型转化,调节自然杀伤细胞活性,进而抑制炎症反应,调控细胞凋亡和自噬,最终逆转肝纤维化进程。本文总结探讨了IL-10家族在抗肝纤维化中的作用机制及其在相关中西医治疗中的应用价值,为肝纤维化治疗提供新的思考。The interleukin-10(IL-10)family is expressed in various types of cells and has a wide range of biological functions,and it plays an important role in the development and progression of hepatic fibrosis.Hepatic fibrosis is a chronic liver disease characterized by abnormal repair of hepatic tissues after injury,activation of hepatic stellate cells,and excessive accumulation of extracellular matrix.The IL-10 family members include IL-10,IL-19,IL-20,IL-22,IL-24,IL-26,IL-28,IL-29,and IL-35,with similarities in structure and function,and changes in their expression levels are closely associated with the progression of hepatic fibrosis.Moderate upregulation of the expression of IL-10 family members can help maintain the quiescent state of hepatic stellate cells,promote the transformation of macrophages to anti-inflammatory phenotype,and regulate the activity of natural killer cells,thereby inhibiting inflammatory response,regulating cell apoptosis and autophagy,and finally reversing the progression of hepatic fibrosis.This article discusses the mechanism of action of IL-10 family members and their application in traditional Chinese medicine and Western medicine therapies,in order to provide new thoughts for the treatment of hepatic fibrosis.

关 键 词：肝纤维化 白细胞介素10 中西医结合 

分 类 号：R575.2[医药卫生—消化系统]