微环境不同组分动态变化调控肝纤维化发展的特征与机制  

The characteristics and mechanism of dynamic changes of different components in microenvironment in regulating the progression of liver fibrosis

作　　者：赵慧兰 刘宗绪 李淑敏 王之枫 刘明慧 盛倩 柯坤彬[2] 石西南 ZHAO Huilan;LIU Zongxu;LI Shumin;WANG Zhifeng;LIU Minghui;SHENG Qian;KE Kunbin;SHI Xinan(College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;Department of Urology,The First Affiliated Hospital of Kunming Medical University,Kunming 650000,China;Key Laboratory of Sustainable Utilization of Yunnan Medicines,College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学中药学院,昆明650500 [2]昆明医科大学第一附属医院泌尿外科,昆明650000 [3]云南中医药大学中药学院暨云南省南药可持续利用研究重点实验室,昆明650500

出　　处：《临床肝胆病杂志》2025年第4期755-760,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82060862);云南省科技厅-云南中医药大学联合重点项目(202101AZ070001-003);云南省科技厅应用基础项目(202301AT070098)。

摘　　要：肝脏有代谢、解毒、免疫防御等功能,肝脏微环境稳态的维持对机体健康极其重要。肝脏的微环境包括肝实质细胞、非实质细胞及非细胞成分等。不同病因导致肝脏慢性损伤性炎症反应,促进肝纤维化的形成和发展。在肝纤维化早、中晚不同时期的动态发展过程中,肝脏微环境的各种成分会发生一系列的变化,而这些能促进肝纤维化的恶性发展。深入探索微环境各成分变化机制对肝纤维化的发生机制和探索潜在的治疗策略至关重要。The liver has diverse functions such as metabolism,detoxification,and immune defense,and the maintenance of hepatic microenvironment homeostasis is crucial for overall bodily health.The hepatic microenvironment consists of the components such as parenchymal cells,non-parenchymal cells,and non-cellular components.Chronic inflammatory responses induced by various etiological factors may promote the formation and progression of liver fibrosis.During the dynamic progression of liver fibrosis,from the early to advanced stages,various components within the hepatic microenvironment undergo a series of changes,which can promote the malignant progression of liver fibrosis.An in-depth exploration of the mechanisms underlying such changes in each component of the liver fibrosis microenvironment is of great significance for understanding the pathogenesis of liver fibrosis and discovering potential treatment strategies.

关 键 词：细胞微环境 肝纤维化 肝星状细胞 枯否细胞 肝窦内皮细胞 

分 类 号：R575[医药卫生—消化系统]