肝硬化患者肌少症与脂质代谢异常的关系及经颈静脉肝内门体分流术干预的潜在益处  

Association between sarcopenia and abnormal lipid metabolism in patients with liver cirrhosis and the potential benefits of transjugular intrahepatic portosystemic shunt

作　　者：李秦念 朱碧莲 唐映梅[1] 张宸瑞 LI Qinnian;ZHU Bilian;TANG Yingmei;ZHANG Chenrui(Department of Gastroenterology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650033,China)

机构地区：[1]昆明医科大学第二附属医院消化内科,昆明650033

出　　处：《临床肝胆病杂志》2025年第4期768-772,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82360108);云南省医学领军人才项目(L-2019013)。

摘　　要：随着肝硬化的进展,患者常常伴随出现肌少症和脂质代谢紊乱,两者之间的复杂相互作用不仅加剧了肝硬化的病程进展,还对患者的预后和生活质量产生了显著影响。而经颈静脉肝内门体分流术(TIPS)作为一种缓解肝硬化相关并发症的有效手段,通过改善肝脏血流动力学,降低门静脉压力,可以在一定程度上改善肌少症。此外,TIPS后血脂水平可能会发生不同程度的变化,这可能与肝脏的代谢功能恢复和血流动力学的改变密切相关。本文旨在介绍肝硬化、肌少症及脂质代谢异常之间的关系,阐述TIPS对肝硬化患者肌少症及脂质代谢异常的影响,探讨其机制及临床意义,为临床治疗提供理论依据。With the progression of liver cirrhosis,patients often develop sarcopenia and lipid metabolism disorders,and the complex interaction between p sarcopenia and lipid metabolism disorders not only promotes the progression of liver cirrhosis,but also affects the prognosis and quality of life of patients.As an effective intervention for alleviating complications associated with liver cirrhosis,transjugular intrahepatic portosystemic shunt(TIPS)can improve sarcopenia to a certain degree by improving hepatic hemodynamics and reducing portal venous pressure.In addition,there might be varying degrees of changes in blood lipid levels after TIPS,which may be closely associated with the recovery of liver metabolic function and the alterations in hemodynamics.This article introduces the association between liver cirrhosis,sarcopenia,and lipid metabolism disorders,elaborates on the effect of TIPS on sarcopenia and abnormal lipid metabolism,and discusses related mechanism and clinical significance,in order to provide a theoretical basis for clinical treatment.

关 键 词：肝硬化 肌减少症 脂代谢障碍 门体分流术 经颈静脉肝内 

分 类 号：R575.2[医药卫生—消化系统]