肿瘤坏死因子超家族因子14(LIGHT)在慢性肝病中的作用机制  

Mechanism of action of tumor necrosis factor superfamily member 14 in chronic liver diseases

作　　者：马亚鹏 马亚楠 MA Yapeng;MA Yanan(Department of Business,Institute of Medical Device Testing Technology,Shanxi Provincial Inspection and Testing Center/Shanxi Institute of Standard Measurement Technology,Taiyuan 030000,China;Cancer Center,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,The Third Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西省检验检测中心(山西省标准计量技术研究院)医疗器械检验技术研究所业务科,太原030000 [2]山西白求恩医院(山西医学科学院,同济山西医院,山西医科大学第三医院)肿瘤中心,太原030000

出　　处：《临床肝胆病杂志》2025年第4期778-783,共6页Journal of Clinical Hepatology

基　　金：山西省自然科学基金(202303021222308);山西白求恩医院人才引进科研启动金(2023RC56)。

摘　　要：肿瘤坏死因子超家族因子14是肿瘤坏死因子超家族的新成员之一,主要通过与功能性受体疱疹病毒侵入介质、淋巴毒素β受体、可溶性诱饵受体3结合介导不同生物学效应,在炎症性疾病、纤维化疾病、抗肿瘤免疫中发挥重要的调节作用。近年来,肿瘤坏死因子超家族因子14在慢性肝病发生发展中的机制及在治疗中的作用日益受到重视。Tumor necrosis factor superfamily member 14(TNFSF14)is a new member of the tumor necrosis factor superfamily member,and it mediates diverse biological functions through binding with herpes virus entry mediator,lymphotoxin-βreceptor,and soluble decoy receptor 3,thereby exerting an important regulatory effect in inflammatory diseases,fibrotic diseases,and antitumor immunity.In recent years,the mechanism of LIGHT in the development and progression of liver diseases and its role in treatment have attracted more and more attention.

关 键 词：肿瘤坏死因子类 肝疾病 信号传导 

分 类 号：R575[医药卫生—消化系统]