肠道源性代谢产物在Alzheimer's病的研究进展  

Research progress of enteric metabolites in Alzheimer's disease

作　　者：陈念 刘聪聪 梁圆 刘子超 王博 宋莉[2] CHEN Nian;LIU Congcong;LIANG Yuan(School of Clinical Medicine,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院临床医学院,272067 [2]济宁医学院附属医院神经内科 [3]济宁医学院法医学与医学检验学院

出　　处：《临床神经病学杂志》2025年第2期143-147,共5页Journal of Clinical Neurology

基　　金：济宁市重点研发计划项目(202203070774)。

摘　　要：肠道微生物与宿主之间的双向沟通作用显著影响大脑功能,越来越多的证据表明肠道菌群失调与Alzheimer's病(AD)的发病密切相关。血液和肠道中的肠道微生物代谢产物,如氧化三甲胺、短链脂肪酸、GABA以及色氨酸代谢物等可能是“微生物群-肠-脑轴”的主要中介物质,对于维持肠道菌群的稳态和肠道黏膜的完整性,调节宿主的免疫系统及认知功能起着不容忽视的作用。本文旨在总结AD疾病发展过程中血液和肠道中微生物的代谢产物,为AD的诊断、治疗提供新的方向。The bidirectional communication between gut microbiome and host significantly affects brain function,and there is increasing evidence that the imbalance of gut microbiota is closely related to the onset of Alzheimer's disease(AD).Blood-and gut-based metabolites,such as trimethylamine oxide,short-chain fatty acids,GABA and tryptophan metabolites,are likely to be the main mediators of the“microbiota-gut-brain axis”,and play an important role in maintaining intestinal flora homeostasis and intestinal mucosal integrity,regulating the host immune system and cognitive function.This paper aims to summarize the blood and intestinal metabolites in the development of AD disease,and provide a new direction for the treatment of AD in the future.

关 键 词：Alzheimer's病 肠道微生物 肠-脑轴 代谢组学 

分 类 号：R749.16[医药卫生—神经病学与精神病学]