重复经颅磁刺激联合双相抑郁三联用药对减少女性青少年非自杀性自伤的疗效评估  

Efficacy evaluation of repeated transcranial magnetic stimulation combined with bipolar depression triple therapy in reducing female adolescents' non-suicidal selfinjury

作　　者：沈韵 李静[3] 邹可[1] 杨宽卫 舒燕萍 郑重[1,3] SHEN Yun;LI Jing;ZOU Ke;YANG Kuanwei;SHU Yanping;ZHENG Zhong(Center of Neurobioassay,West China Hospital of Sichuan University,Chengdu 610041,P.R.China;Women's Mental Health Branch,Second People's Hospital of Guizhou Province,Guiyang 550004,P.R.China;Center of Neuroregulation and Detection,West China Xiamen Hospital of Sichuan University,Xiamen 361022,P.R.China)

机构地区：[1]四川大学华西医院神经生物检测中心,成都610041 [2]贵州省第二人民医院妇女精神卫生科,贵阳550004 [3]四川大学华西厦门医院神经调控与检测中心,厦门361022

出　　处：《生物医学工程学杂志》2025年第2期288-292,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金(81873354,82460282);四川省科技厅项目基金(2023NSFSC0125);贵州省科技计划项目(ZK-2023-一般195)。

摘　　要：为探究有效减少女性青少年非自杀性自伤(NSSI)行为的方法,选择四川大学华西医院及贵州省第二人民医院2021年6月至2024年6月女性青少年存在急性NSSI行为的患者共45例,随机分为A、B、C组,每组15例,A组采用重复经颅磁刺激(rTMS)联合双相抑郁三联用药治疗,B组采用双相抑郁三联用药治疗,比较有效性和安全性,C组采用双相抑郁三联用药联合仅有刺激声响但不产生刺激性磁场的伪刺激,作为对照研究。A组治疗后汉密尔顿抑郁评分(HAMD)、汉密尔顿焦虑评分(HAMA)、自杀风险因素评估评分(NGASR)明显低于B、C组(P <0.01)。rTMS联合双相抑郁三联用药对减少女性青少年NSSI有确切疗效,可减少患者短期内NSSI行为的发生率。In order to explore effective ways to reduce non-suicidal self-injury(NSSI) among female adolescents, a total of 45 female adolescent patients with NSSI in West China Hospital of Sichuan University and Guizhou Second Provincial People's Hospital from June 2021 to June 2024 were selected randomly that divided into groups A, B and C,with 15 cases in each group. Group A was treated with repeated transcranial magnetic stimulation(rTMS) and bipolar depression triple therapy, and group B was treated with bipolar depression triple therapy to compare the effectiveness and safety. Group C received bipolar depression triple therapy combined with sham stimulation which only produced stimulating sounds but no stimulating magnetic field as a control in the study. After treatment, the Hamilton Anxiety Score(HAMA), Hamilton Depression Score(HAMD) and Nurses' Global Assessment of Suicide Risk(NGASR) in group A were significantly lower than those in group B and C(P < 0.01). rTMS combined with bipolar depression triple therapy has a definite effect on reducing NSSI in female adolescents, which can reduce the incidence rate of short-term NSSI behavior in patients.

关 键 词：重复经颅磁刺激 双相抑郁三联用药 女性青少年非自杀性自伤 

分 类 号：R749.4[医药卫生—神经病学与精神病学]