基于计算机断层扫描影像的人牙槽骨多孔超弹特性预测模型研究  

A study on the predictive model of porous hyperelastic properties of human alveolar bone based on computed tomography imaging

作　　者：吴斌[1] 栗明娜 杨帆 袁乐 卢轶 姜迪 易扬 严斌[2,3,4] WU Bin;LI Mingna;YANG Fan;YUAN Le;LU Yi;JIANG Di;YI Yang;YAN Bin(School of Mechanical and Electronic Engineering,Nanjing Forestry University,Nanjin 210037,P.R.China;Department of Orthodontics,The Affiliated Stomatological Hospital of Nanjing Medical University,Nanjin 210029,P.R.China;Jiangsu Province Key Laboratory of Oral Diseases,Nanjin 210029,P.R.China;Jiangsu Province Engineering Research Center of Stomatological Translation Medicine,Nanjin 210029,P.R.China)

机构地区：[1]南京林业大学机械电子工程学院,南京210037 [2]南京医科大学附属口腔医院正畸科,南京210029 [3]江苏省口腔疾病研究重点实验室,南京210029 [4]江苏省口腔转化医学工程研究中心,南京210029

出　　处：《生物医学工程学杂志》2025年第2期359-365,373,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金(82071143,51305208);江苏省重点研发计划(BE2022795);江苏省卫生健康委员会重点医学研究项目(ZDA202003);江苏省口腔疾病研究重点实验室研究基金(JSKLOD-KF-1901)。

摘　　要：牙槽骨重建仿真是量化正畸的有效手段,但目前无法直接获得仿真用的人体活体牙槽骨材料模型。本研究引入三维随机多孔材料的等效剪切模量预测方法,融合一阶奥格登(Ogden)超弹性模型针对人牙槽骨构建了基于计算机断层扫描(CT)影像的多孔超弹性特性Ogden模型(CT-PHO),并综合显微CT(MicroCT)、纳米压痕实验和单轴压缩实验数据结果获得模型参数。与以往的预测模型相比,CT-PHO模型在任意骨密度条件下均能表现出更低的均方根误差(RMSE)。通过单轴压缩实验仿真证明,采用CT-PHO模型参数的仿真能更精确模拟牙槽骨受压时的力学特性;再对不同个体人牙槽骨样本进一步预测验证,准确的预测结果证明了CT-PHO模型的通用性。研究表明,本文所提CT-PHO模型可测算人体活体牙槽骨的材料特性,今后或可用于骨重建仿真来指导临床诊疗。Alveolar bone reconstruction simulation is an effective means for quantifying orthodontics, but currently, it is not possible to directly obtain human alveolar bone material models for simulation. This study introduces a prediction method for the equivalent shear modulus of three-dimensional random porous materials, integrating the firstorder Ogden hyperelastic model to construct a computed tomography(CT) based porous hyperelastic Ogden model(CTPHO) for human alveolar bone. Model parameters are derived by combining results from micro-CT, nanoindentation experiments, and uniaxial compression tests. Compared to previous predictive models, the CT-PHO model shows a lower root mean square error(RMSE) under all bone density conditions. Simulation results using the CT-PHO model parameters in uniaxial compression experiments demonstrate more accurate prediction of the mechanical behavior of alveolar bone under compression. Further prediction and validation with different individual human alveolar bone samples yield accurate results, confirming the generality of the CT-PHO model. The study suggests that the CT-PHO model proposed in this paper can estimate the material properties of human alveolar bone and may eventually be used for bone reconstruction simulations to guide clinical treatment.

关 键 词：牙槽骨 预测模型 超弹性 骨密度 有限元仿真 

分 类 号：R783.5[医药卫生—口腔医学]