重复经颅磁刺激改善帕金森病抑郁研究进展  

Research progress on repetitive transcranial magnetic stimulation for improving depression in Parkinson’s disease

作　　者：卢苇 何宝峰 李娟[1] 文明明(综述) 张敏(审校)[3] LU Wei;HE Baofeng;LI Juan;WEN Mingming;ZHANG Min(Department of Rehabilitation Medicine,Gansu Provincial Hospital,Lanzhou 730000,P.R.China;College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,P.R.China;Second Ward of Department of Neurology,Gansu Provincial Hospital,Lanzhou 730000,P.R.China)

机构地区：[1]甘肃省人民医院康复医学科,兰州730000 [2]甘肃中医药大学药学院,兰州730000 [3]甘肃省人民医院神经内科二病区,兰州730000

出　　处：《生物医学工程学杂志》2025年第2期404-408,共5页Journal of Biomedical Engineering

基　　金：甘肃省自然科学基金资助项目(21JR7RA597,24JRRA1052,22JR5RA673);甘肃省脑血管病临床研究中心资助项目(20JR10RA431);甘肃省人民医院院内基金资助项目(24KYQDJ-B-44)。

摘　　要：帕金森病是好发于中老年人的神经退行性疾病,表现为黑质多巴胺能神经元进行性丧失和路易小体聚集,从而引起一系列运动症状和非运动症状。抑郁是帕金森病非运动症状最主要的表现形式,严重影响患者生活质量。临床医生常用抗抑郁药物给药等方式改善帕金森病患者的抑郁症状,但仍亟待解决此类方式带来的药物毒副作用及耐药性问题。而重复经颅磁刺激是一种安全、无创的神经调控技术,可以改变皮质脊髓束兴奋性,诱导多巴胺等多种神经递质释放,进一步改善帕金森病患者的抑郁症状。基于此,本文探讨总结了国内外采用重复经颅磁刺激的方式改善帕金森病抑郁的疗效及其潜在作用机制的研究进展,以期为相关临床应用研究提供参考。Parkinson's disease is a neurodegenerative disease that mostly occurs in middle-aged and elderly people. It is characterized by progressive loss of dopaminergic neurons in the substantia nigra and aggregation of Lewy bodies, resulting in a series of motor symptoms and non-motor symptoms. Depression is the most important manifestation of non-motor symptoms, which seriously affects the quality of life of patients. Clinicians often use antidepressant drugs to improve the depressive symptoms of patients with Parkinson 's disease, but it is still urgent to solve the problems of drug side effects and drug resistance caused by such methods. Repetitive transcranial magnetic stimulation is a safe and non-invasive neuromodulation technique that can change the excitability of the corticospinal tract, induce the release of dopamine and other neurotransmitters, and further improve the depressive symptoms of patients with Parkinson 's disease. Based on this, this paper discusses and summarizes the research progress on the efficacy and potential mechanism of repetitive transcranial magnetic stimulation for improving depression in Parkinson 's disease at home and abroad, in order to provide reference for related clinical application research.

关 键 词：重复经颅磁刺激 帕金森病 抑郁 

分 类 号：R742.5[医药卫生—神经病学与精神病学]