炎症性肠病与环境因素的研究进展:从暴露到基因表达调控  

Research progress of inflammatory bowel disease and environmental factors:from exposure to gene expression regulation

作　　者：钱雨昕 孙誉郝 傅甜 景方敏 陈杰[1] 王晓艳[1] Qian Yuxin;Sun Yuhao;Fu Tian;Jing Fangmin;Chen Jie;Wang Xiaoyan(Department of Gastroenterology,the Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Gastroenterology,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Department of Gastroenterology,Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University,Hangzhou 310009,China)

机构地区：[1]中南大学湘雅三医院消化内科,长沙410013 [2]浙江大学医学院附属第二医院消化内科,杭州310006 [3]西湖大学医学院附属杭州市第一人民医院消化内科,杭州310009

出　　处：《中华炎性肠病杂志(中英文)》2025年第2期118-124,共7页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金(82170553、U23A20492);湖南省自然科学基金(2024J1014);湖南省科技厅芙蓉实验室科研攻关项目(2023SK2085-3);中南大学湘雅三医院学科建设双PI"项目(202401);湖南省优秀青年科学基金项目(2025JJ40083)。

摘　　要：炎症性肠病(IBD)是一种慢性非特异性肠道炎性疾病,受遗传和环境共同影响。空气污染物、重金属、工业污染物、有机污染物、饮食、生活方式等生态和社会环境因素会影响IBD的发生发展,并通过表观遗传学、肠道微生物等途径影响IBD的基因表达调控。本文总结环境因素对IBD发生发展的作用,并探讨其影响基因表达调控的方式。Inflammatory bowel disease(IBD)is a chronic and nonspecific disease affected by both genetic and environmental factors.Ecological and social environmental factors,including air pollutants,heavy metals,industrial pollutants and organic pollutants,diet,and lifestyle,influence the occurrence and development of IBD and regulate IBD gene expression through epigenetics and gut microbiota.This article summarizes the role of environmental factors in IBD and explores the ways in which they influence the regulation of gene expression.

关 键 词：炎症性肠病 环境因素 表观遗传学 肠道微生物 基因表达调控 

分 类 号：R574[医药卫生—消化系统]