肠道神经系统紊乱在克罗恩病中的意义  

Significance of enteric nervous system disorders in Crohn's disease

作　　者：邓雪[1,2] 杨玲玲 张玥 郭红 王微 唐雪峰 Deng Xue;Yang Lingling;Zhang Yue;Guo Hong;Wang Wei;Tang Xuefeng(Chongqing Medical University,Chongqing 400016,China;Department of Pathology,Chongqing General Hospital,Chongqing 401120,China;Department of Gastroenterology,Chongqing General Hospital,Chongqing 401120,China)

机构地区：[1]重庆医科大学,重庆400016 [2]重庆市人民医院病理科,重庆401120 [3]重庆市人民医院消化内科,重庆401120

出　　处：《中华炎性肠病杂志(中英文)》2025年第2期158-163,共6页Chinese Journal of Inflammatory Bowel Diseases

基　　金：重庆市技术创新与应用发展重点项目(2022TIADKPX0243);重庆市科卫联合医学科技创新项目(2023MSXM034)。

摘　　要：克罗恩病(CD)是一种病因不明的肠道炎症性疾病,病理生理学机制尚不清楚。肠道神经系统(ENS)负责肠道功能的自主调节,研究发现ENS功能障碍可能是CD病理生理学机制的关键环节。本文综述ENS在CD发生发展过程中的病理生理机制,以及其异常组织学表现和神经丛炎对预测CD术后复发的意义。Crohn's disease(CD)is an intestinal inflammatory disease of unknown etiology,the pathophysiological mechanism is still unclear.The enteric nervous system(ENS)is responsible for the autonomous regulation of intestinal function.Therefore,ENS dysfunction may be the core of the pathophysiological mechanism of CD.Here,we review the pathophysiological mechanism by which ENS contributes to the development of CD,with a focus on the role of aberrant histological manifestations of ENS and plexitis in predicting the recurrence of CD following surgery.

关 键 词：克罗恩病 肠道神经系统 病理生理机制 组织学表现 神经丛炎 复发 

分 类 号：R574.62[医药卫生—消化系统]