真性小眼球眼部生物学参数与临床特征的临床研究  

Analysis of biological parameters and clinical features of nanophthalmos

作　　者：陶靖[1] 曹凯[2] 王进达[1] Jing Tao;Kai Cao;Jinda Wang(Beijing Tongren Eye Center,Beijing Tongren Hospital,CapitalMedical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100730,China;Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100005,China)

机构地区：[1]首都医科大学附属北京同仁医院、北京同仁眼科中心、眼科学与视觉科学北京市重点实验室,100730 [2]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所,眼科学与视觉科学北京市重点实,100005

出　　处：《中华眼科医学杂志(电子版)》2025年第1期6-12,共7页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：国家自然科学基金项目(30700920);北京市科技新星计划资助项目(2005B50)。

摘　　要：目的探讨真性小眼球(NNO)患者的眼部生物学参数与临床特征。方法收集2003年1月至2024年12月于首都医科大学附属北京同仁医院眼科中心就诊的NNO患者54例(100只眼)。其中,男性27例(51只眼),女性27例(49只眼);年龄1~67岁,平均年龄(39.3±16.5)岁。询问或检测NNO患者病史、眼部生物学参数及并发症。其中,生物学参数包括眼轴(AL)、最佳矫正视力(BCVA)、等效球镜屈光度(SE)、眼压(IOP)、角膜横径(TCD)、中央角膜厚度(CCT)、前房深度(ACD)、晶状体厚度(LT)、黄斑中心凹视网膜厚度(FRT)、脉络膜厚度(SFCT)及前巩膜厚度(AST)等均符合正态分布,采用¯x±s进行描述。NNO主要并发症包括高度远视、弱视、闭角型青光眼(ACG)及葡萄膜渗漏综合征(UES)等,其发生的占比情况采用例数(眼数)和百分比进行描述。采用Spearman秩相关进行生物学参数之间的相关性分析。结果全部NNO患者54例(100只眼)的AL、LogMARBCVA、SE、IOP、TCD、CCT、ACD、LT、FRT、SFCT及AST等眼部生物学参数的检测结果分别为(16.22±1.31)mm、1.11±0.78、(14.1±2.74)D、(25.3±13.3)mmHg(1mmHg=0.133kPa)、(10.32±0.79)mm、(561±37)μm、(2.54±0.42)mm、(4.89±0.55)mm、(381±133)μm、(375±85)μm及(0.74±0.08)mm。各生物学参数之间的相关性分析结果分别为AL与LT呈正相关,与SE及FRT呈负相关,其相关性具有统计学意义(r=0.365,-0.474,-0.500;P<0.05);ACD与TCD及FRT呈正相关,与IOP、CCT及LT呈负相关,其相关性具有统计学意义(r=0.380,0.506,-0.281,-0.315,-0.276;P<0.05);AST与FRT呈正相关,与SFCT呈负相关,其相关性具有统计学意义(r=0.503,-0.557;P<0.05)。NNO并发症占比分别为高度远视入组34例(61只眼),患病34例(61只眼),占100%;弱视入组52例(96只眼),患病52例(93只眼),占96.88%;ACG入组50例(92只眼),患病35例(62只眼),占67.39%;UES入组50例(91只眼),患病33例(59只眼),占64.83%。UES病情由轻到重表现分别为睫状体脱离入组41例(73只�ObjectiveTo investigate the ocular biological parameters and clinical characteristics of a rare ocular disease nanophthalmos(NNO).MethodsA total of 54 patients(100 eyes)with NNO who visited the Ophthalmology Center of Beijing Tongren Hospital affiliated with Capital Medical University from January 2003 to December 2024 were collected.Among them,there were 27 males(51 eyes)and 27 females(49 eyes)with an average age of(39.3±16.5)years(ranging from 1 to 67 years).The clinical data of NNO patientswere analyzed,includingmedical history,ophthalmic examination results,ocular biological parameters,ResultsThe ocular biological parameter measurements of NNO patients showed that AL,BCVA,SE,IOP,TCD,CCT,ACD,LT,FRT,SFCT,and ASTwere(16.22±1.31)mm,(1.11±0.78)logarithm of theminimum angle of resolution(logMAR),(14.1±2.74)D,(25.3±13.3)mmHg(1 mmHg=0.133 kPa),(10.32±0.79)mm,(561±37)μm,(2.54±0.42)mm,(4.89±0.55)mm,(381±133)μm,(375±85)μm,and(0.74±0.08)mm,respectively.The correlation analysis of biological parameters showed that AL was positively correlated with LT and negatively correlated with SE and FRT,with statistically significant correlations(r=0.365,-0.474,-0.500;P<0.05);ACD was positively correlated with TCD and FRT and negatively correlated with IOP,CCT,and LT,with statistically significant correlations(r=0.380,0.506,-0.281,-0.315,-0.276;P<0.05);AST was positively correlated with FRT and negatively correlated with SFCT,with statistically significant correlations(r=0.503,-0.557;P<0.05).The analysis results of the proportion of NNO complicationswere:high hyperopia was included in 34 cases(61 eyes),with 34 cases(61 eyes)affected,accounting for 100%;amblyopia was included in 52 cases(96 eyes),with 52 cases(93 eyes)affected,accounting for 96.88%;ACG was included in 50 cases(92 eyes),with 35 cases(62 eyes)affected,accounting for 67.39%;UES was included in 50 cases(91 eyes),with 33 cases(59 eyes)affected,accounting for 64.83%.The severity of UES ranged from mild to severe as follows:ciliary body detachmentwas included

关 键 词：真性小眼球 生物学特征 临床特征 

分 类 号：R77[医药卫生—眼科]