替加环素耐药机制研究进展  

Progress in research of mechanism of tigecycline resistance

作　　者：刘璐 刘馨月 贾芳 Liu Lu;Liu Xinyue;Jia Fang(Inner Mongolia Key Laboratory of Molecular Biology,School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia,China;Ordos Central Hospital,Ordos 017000,Inner Mongolia,China;The First Clinical Medical College,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia,China)

机构地区：[1]内蒙古医科大学基础医学院,内蒙古自治区分子生物学重点实验室,内蒙古呼和浩特010110 [2]鄂尔多斯市中心医院,内蒙古鄂尔多斯017000 [3]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010110

出　　处：《疾病监测》2025年第3期384-390,共7页Disease Surveillance

基　　金：内蒙古自治区自然科学基金项目(No.2023LHMS08014);内蒙古医科大学“创客培育”项目(No.101322024078)。

摘　　要：多重耐药菌的出现,给临床抗感染的治疗带来极大的挑战,而替加环素作为一种新型的四环素类药物被用于“最后一道防线”。但近年来替加环素耐药多有报道,本研究旨在对目前替加环素耐药机制包括主动外排泵、基因突变、Tet家族等研究进展进行综述,以期为解决替加环素多重耐药问题提供更多的思路。The emergence of multi-drug resistant bacteria has brought great challenges to clinical anti-infection treatment,and tigecycline,a new tetracycline drug,is used as the“last line drug”.But in recent years,there have been many reports of tigecycline resistance.This paper summarizes the mechanisms of tigecycline resistance,including active efflux pump,gene mutation and Tet family,to provide more ideas for the prevention of multi-drug resistance to tigecycline.

关 键 词：替加环素 耐药机制 主动外排泵 基因突变 

分 类 号：R211[医药卫生—中医学] R378