Cancer phylogenetic inference using copy number alterations detected from DNA sequencing data  

在线阅读下载全文

作  者:Bingxin Lu 

机构地区:[1]School of Biosciences and Medicine,University of Surrey,Guildford GU27XH,UK [2]Surey Institute for Pepleentred Arificial Inteligence,University of Surrey,Guildford GU2XH,UK

出  处:《Cancer Pathogenesis and Therapy》2025年第1期16-29,共14页癌症发生与治疗(英文)

摘  要:Cancer is an evolutionary process involving the accumulation of diverse somatic mutations and clonal evolution over time.Phylogenetic inference from samples obtained from an individual patient offers a powerful approach to unraveling the intricate evolutionary history of cancer and provides insights that can inform cancer treatment.Somatic copy number alterations(CNAs)are important in cancer evolution and are often used as markers,alone or with other somatic mutations,for phylogenetic inferences,particularly in low-coverage DNA sequencing data.Many phylogenetic inference methods using CNAs detected from bulk or single-cell DNA sequencing data have been developed over the years.However,there have been no systematic reviews on these methods.To summarize the state-of-the-art of the field and inform future development,this review presents a comprehensive survey on the major challenges in inference,different types of methods,and applications of these methods.The challenges are discussed from the aspects of input data,models of evolution,and inference algorithms.The different methods are grouped according to the markers used for inference and the types of the reconstructed trees.The applications include using phylogenetic inference to understand intra-tumor heterogeneity,metastasis,treatment resistance,and early cancer development.This review also sheds light on future directions of cancer phylogenetic inference using CNAs,including the improvement of scalability,the utilization of new types of data,and the development of morerealisticmodelsof evolution.

关 键 词:Clonal evolution Phylogenetic inference Somatic mutation Copy numberchange Chromosomal instability 

分 类 号:R730.2[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象