Rasmussen脑炎发病机制及治疗进展  

Research progress on pathogenesis and treatment of Rasmussen encephalitis

作　　者：吴红梅 季涛云[2] 张继新[1] WU Hong-mei;JI Tao-yun;ZHANG Ji-xin(Department of Pathology,Peking University First Hospital,Beijing 100034,China;Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院病理科,100034 [2]北京大学第一医院儿科,100034

出　　处：《中国现代神经疾病杂志》2025年第3期265-270,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家重点研发计划项目(项目编号:2022YFC2705205);中央高水平医院临床科研业务费资助项目(北京大学第一医院交叉研究专项课题,项目编号:2024IR23)。

摘　　要：Rasmussen脑炎的发病机制尚未明确,目前病毒感染机制、抗体介导的体液免疫机制、T淋巴细胞介导的细胞免疫机制及小胶质细胞介导的神经退行性变机制可能与疾病发生发展过程相关。疾病早期针对T淋巴细胞和小胶质细胞的免疫治疗可延缓部分患者疾病进展。本文对Rasmussen脑炎主要发病机制学说和最新治疗进展进行综述,以提高临床对疾病的认识,并为治疗提供指导。The pathogenesis of Rasmussen encephalitis(RE)remains unclear.Current theories suggest that viral infection,antibody-mediated humoral immune mechanisms,T lymphocytes mediated cellular immunity,and microglia mediated neurodegeneration may all be involved in disease onset and progression.In the early stage of disease,immunotherapy targeting induced by T lymphocytes and microglia could slow down disease progression of some patients.This review summarizes the latest research on the main pathogenic hypotheses and treatment strategies for RE,aiming to enhance clinical understanding of the disease and provide guidance for therapeutic interventions.

关 键 词：脑炎 癫痫 病理学 免疫疗法 综述 

分 类 号：R742.1[医药卫生—神经病学与精神病学]