The regulatory role of lncRNA in tumor drug resistance:refracting light through a narrow aperture  

作　　者：HENG ZHANG XIAO YANG YUJIN GUO HAIBO ZHAO PEI JIANG QING-QING YU 

机构地区：[1]Department of Laboratory,Shandong Daizhuang Hospital,Jining,272051,China [2]Department of Anesthesiology,Affiliated Hospital of Jining Medical University,Jining,272000,China [3]Department of Clinical Pharmacy,Jining No.1 People’s Hospital,Jining,272002,China [4]Department of Oncology,Jining No.1 People’s Hospital,Jining,272002,China [5]Translational Pharmaceutical Laboratory,Jining No.1 People’s Hospital,Jining,272002,China

出　　处：《Oncology Research》2025年第4期837-849,共13页肿瘤学研究(英文)

基　　金：supported by the grant of the Medicine and Health Care Science and Technology Development Plan Projects Foundation of Shandong Province(No.202301060260).

摘　　要：As living conditions improve and diagnostic capabilities advance,the incidence of tumors has increased,with cancer becoming a leading cause of death worldwide.Surgery,chemotherapy,and radiotherapy are the most common treatments.Despite advances in treatment options,chemotherapy remains a routine first-line treatment for most tumors.Due to the continuous and extensive use of chemotherapy drugs,tumor resistance often develops,becoming a significant cause of treatment failure and poor prognosis.Recent research has increasingly focused on how long stranded noncoding RNAs(LncRNAs)influence the development of malignant tumors and drug resistance by regulating gene expression and other biological mechanisms during cell growth.Studies have demonstrated that variations in lncRNA expression levels,influenced by both interpatient variability and intratumoral genetic and epigenetic differences,are closely linked to tumor drug resistance.Therefore,this review advocates using lncRNA as a framework to investigate the regulation of genes associated with drug resistance,proposing lncRNA-targeted therapeutic strategies to potentially increase the efficacy of chemotherapy,improve patient outcomes,and guide future research directions.

关 键 词：Long chain non coding RNA(LncRNA) Gene regulatory mechanisms Tumor resistance CHEMOTHERAPY 

分 类 号：R730.5[医药卫生—肿瘤]