特发性震颤的非运动症状及黑质超声的相关研究  

Features of non-motor symptoms and substantia nigra ultrasound in essential tremor

作　　者：陈学姣 邢秀颖 刘彬[3] 任宁[3] 李欣 陈蕾[3] CHEN Xuejiao;XING Xiuying;LIU Bin(Shanxi Provincial Coal Central Hospital,Taiyuan 030006,China)

机构地区：[1]山西省煤炭中心医院,山西太原030006 [2]天津医科大学神经内外科及神经康复临床学院,天津300070 [3]天津市环湖医院,天津300350

出　　处：《中风与神经疾病杂志》2025年第4期306-309,F0002,共5页Journal of Apoplexy and Nervous Diseases

基　　金：天津市教委科研计划项目(自然科学)(2024ZD064)。

摘　　要：目的探究特发性震颤(ET)患者的非运动症状及经颅黑质超声特点。方法对50例ET患者及50例健康对照者进行一般资料的收集、非运动症状量表评估及经颅黑质超声(TCS)检查。通过t检验、非参数检验及χ^(2)检验比较两组患者的一般资料、量表评估结果及TCS结果。结果ET组和健康对照组在NMSS总分、MoCA总分、认知障碍发生率、HAMA总分、中重度焦虑发生率、HAMD总分、PSQI总分、睡眠不佳发生率、ESS总分、日间嗜睡发生率、FSS总分上差异均具有统计学,而在中重度抑郁发生率、疲劳发生率上差异无统计学意义。两组在“左侧高回声”“右侧高回声”“双侧高回声”“S/M值”“至少一侧高回声面积>0.2 cm2的例数”“S/M比值>7%的例数”“TCS阳性的例数”上差异均无统计学意义。结论ET患者较正常人更容易伴发认知功能受损、焦虑、抑郁、睡眠质量不佳、日间嗜睡及疲劳,应在临床中对该疾病的非运动症状予以更多的关注。TCS检查对于ET患者及健康人的诊断价值较小。Objective To investigate the features of non-motor symptoms and transcranial substantia nigra ultrasound in essential tremor(ET).Methods General data were collected from 50 patients with ET and 50 healthy controls,and non-motor symptom scales and transcranial nigra sonography(TCS)were used for assessment.The t-test,the non-parametric test,and the chi-square test were used for comparison of general data,scale assessment results,and TCS findings between the two groups.Results There were significant differences between the ET group and the healthy control group in the total scores of NMSS,MoCA,HAMA,HAMD,PSQI,ESS,and FSS and the incidence rates of cognitive impairment,moderate or severe anxiety,poor sleep,and daytime sleepiness,while there were no significant differences in the incidence rates of moderate or severe depression and fatigue between the two groups.There were no significant differences between the two groups in terms of“hyperechoic area of the left side”“hyperechoic area of the right side”“hyperechoic area of both sides”“S/M value”“the number of cases with a hyperechoic area of>0.2 cm2 for at least one side”“the number of cases with an S/M ratio of>7%”and“the number of cases with positive TCS results”.Conclusion Compared with healthy controls,ET patients are more susceptible to cognitive impairment,anxiety,depression,poor sleep quality,daytime sleepiness,and fatigue,and the non-motor symptoms of ET should be taken seriously in clinical practice.TCS examination has a relatively low diagnostic value in ET patients and healthy individuals.

关 键 词：特发性震颤 非运动症状 经颅黑质超声 

分 类 号：R742.5[医药卫生—神经病学与精神病学]