修和方加减联合化疗治疗卵巢癌手术切除后临床观察  

The effects of modified Xiuhe prescription combined with paclitaxel and platinum on the patients with surgically resected ovarian cancer

作　　者：殷蓓丽 蔡奚梅 钱云英[1] 须慕棠 YIN Beili;CAI Ximei;QIAN Yunying;XU Mutang(Department of Obstetrics and Gynecology,Changshu Traditional Chinese Medicine Hospital,Changshu 215500,China)

机构地区：[1]常熟市中医院妇产科,江苏常熟215500

出　　处：《陕西中医》2025年第5期634-637,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：江苏省妇幼健康科研项目(F202014)。

摘　　要：目的:评价修和方加减联合紫杉醇(PTX)+铂类方案对手术切除气血两虚型卵巢癌(OC)患者近远期预后、中医证候和免疫功能的影响。方法:选取接受手术切除治疗的气血两虚型OC患者80例,根据术后治疗方案不同分为化疗组(PTX+铂类方案)和联合组(修和方加减联合PTX+铂类方案),各40例。观察并比较两组患者的近远期预后、中医证候改善情况以及免疫功能变化。结果:联合组客观有效率明显高于化疗组(77.50%与52.50%,P<0.05),中位PFS和中位OS亦显著长于化疗组(P<0.05);两组治疗后中医证候总积分均较治疗前明显减少(P<0.05),而联合组减少幅度更大(P<0.05);联合组治疗后CD4^(+)、CD4^(+)/CD8^(+)、NK细胞活性明显高于化疗组,CD8^(+)显著低于化疗组(P<0.05);联合组与化疗组在不良反应的分级中比较有统计学差异(P<0.05)。结论:修和方加减联合PTX+铂类方案能够显著提高手术切除OC(气血两虚证)患者的近远期疗效,改善中医证候,增强患者的免疫功能,用药具有一定安全性。Objective:To evaluate the effects of modified Xiuhe Prescription combined with paclitaxel(PTX)and platinum on the short-term and long-term prognosis,traditional Chinese medicine syndromes,and immune function of patients with surgically resected ovarian cancer(OC)of qi and blood deficiency type.Methods:80 patients with qi and blood deficiency type OC who underwent surgical resection were selected and divided into a chemotherapy group(PTX+platinum)and a combination group(modified Xiuhe prescription combined with PTX+platinum)according to different postoperative treatment plans,with 40 patients in each group.Observe and compare the short-term and long-term prognosis,improvement of traditional Chinese medicine syndromes,and changes in immune function between two groups of patients.Results:The objective effective rate of the combination group was higher than that of the chemotherapy group(77.50%vs.52.50%,P<0.05),and the median PFS and median OS were also longer than those of the chemotherapy group(P<0.05).After treatment,the total score of traditional Chinese medicine syndrome in both groups decreased compared to before treatment(P<0.05),with a greater decrease in the combination group(P<0.05).After treatment,the CD4^(+),CD4^(+)/CD8^(+),and NK cell activity in the combination group were significantly higher than those in the chemotherapy group,while CD8^(+)was significantly lower than that in the chemotherapy group(P<0.05).The combination group and the chemotherapy group compared in the grade of myelosuppression,gastrointestinal reaction,neurological and hepatorenal toxicity(P<0.05).Conclusion:The combination of modified Xiuhe Prescription and PTX+platinum can significantly improve the short-and long-term efficacy of surgical resection of OC(Qi and Blood Deficiency Syndrome)patients,improve traditional Chinese medicine syndromes,enhance patients’immune function,and has certain safety.

关 键 词：卵巢癌 气血两虚证 修和方加减 PTX 铂类 预后 中医证候 免疫功能 

分 类 号：R737.31[医药卫生—肿瘤]