从肾小球系膜与膜原联系探讨IgA肾病病机与证治  

Integrating the glomerular mesangium and Mo Yuan theory for the management of IgA nephropathy

作　　者：常悦 白云绮 严嘉欣 陈振杰 周静威[1] CHANG Yue;BAI Yunqi;CHEN Zhenjie;ZHOU Jingwei(Dongzhimen Hospital,Beijing University of Chinese Medicine Department of Nephrology,Beijing 100070,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东直门医院肾病科,北京100070 [2]北京中医药大学,北京100029

出　　处：《陕西中医》2025年第5期651-655,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助面上项目(81874401);中央高校基本科研业务费专项资金资助项目(2020-JYB-ZDGG-118)。

摘　　要：IgA肾病的主要病理特征为肾小球系膜增生伴IgA为主的免疫复合物沉积,最近的研究表明黏膜免疫尤其是肠道黏膜免疫在IgA肾病的发生发展中起到关键作用。在现代膜原理论中,黏膜免疫屏障可归入广义膜原的范畴。本文立论于在中医视角下人体膜系的整体性,以中医“象思维”视角将肾小球系膜抽象为人体微观之膜原,从IgA肾病中微观膜原与宏观膜原的联系的角度,尝试提出了IgA肾病宏观膜原与微观膜原共病,肾络与肾中膜原相互影响的病机特点,并尝试针对这一特点论治IgA肾病。ed as the micro-scale“Mo Yuan”within the human body.The paper explores the relationship between the micro-scale and macro-scale“Mo Yuan”in IgA nephropathy,attempting to propose a pathogenic characteristic where the macro-scale“Mo Yuan”and micro-scale“Mo Yuan”coexist,and the renal vessels and the renal“Mo Yuan”mutually influence each other.Furthermore,the paper endeavors to discuss the treatment of IgA nephropathy based on this characteristic.

关 键 词：IGA肾病 膜原理论 伏邪理论 肾小球系膜 肾脏微观病理 

分 类 号：R592.31[医药卫生—老年医学]