中草药及其活性成分在结直肠癌防治中的作用和机制  

Role and mechanism of Chinese herbal medicine and its active ingredients in the prevention and treatment of colorectal cancer

作　　者：徐洋[1,2,3] 于晓辉[1,2,3] 高浏璐 石嘉琪[2] 卢利霞 王俊科 XU Yang;YU Xiaohui;GAO Liulu;SHI Jiaqi;LU Lixia;WANG Junke(Lanzhou University,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]兰州大学,甘肃兰州730000 [2]中国人民解放军联勤保障部队第九四○医院,甘肃兰州730050 [3]中国人民解放军联勤保障部队第九四○医院基础医学实验室甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

出　　处：《中国临床研究》2025年第4期652-656,共5页Chinese Journal of Clinical Research

基　　金：甘肃省科技计划基础研究项目(22JR11RA009);甘肃省科技计划创新基地和人才计划项目(21JR7RA017)。

摘　　要：结直肠癌(colorectal cancer, CRC)是常见的消化道恶性肿瘤,治疗方案多为手术及靶向治疗,但毒副作用及复发率较高,患者依从性较差。大量的临床试验支持中草药预防和治疗CRC的有效性,其具有安全性高、不良反应小等优势,在CRC防治方面呈现出较大潜力。本文综述中草药及其活性成分在CRC治疗中的作用及机制,以期为中草药及其活性成分抗CRC的研究及临床应用提供理论依据和参考价值。Colorectal cancer(CRC)is a common gastrointestinal malignant tumor.The existing treatment options are surgery and targeted therapy,the toxic side effects and recurrence rate are high,and the patient compliance is poor.More and more clinical trials support the effectiveness of Chinese herbal medicine in the prevention and treatment of CRC,which has advantages of high safety and low adverse reactions,showing great potential in the prevention and treatment of CRC.This article reviews the role and mechanism of Chinese herbal medicine and its active components in the treatment of CRC,in order to provide a theoretical basis and reference value for the research and clinical application of Chinese herbal medicine and its active components against CRC.

关 键 词：中草药 活性成分 结直肠癌 恶性肿瘤 

分 类 号：R574.6[医药卫生—消化系统]