肿瘤相关巨噬细胞在食管和胃肠道恶性肿瘤中的研究进展  

Progress of Research on Tumor⁃associated Macrophages in Esophageal and Gastrointestinal Malignancies

作　　者：杨辰钰 许浩然 张清淋 占强 YANG Chenyu;XU Haoran;ZHANG Qinglin;ZHAN Qiang(Department of Gastroenterology,the Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi Medical Center of Nanjing Medical University,Jiangsu Branch of the National Clinical Research Center for Digestive Diseases,Wuxi,Jiangsu Province,214023)

机构地区：[1]南京医科大学附属无锡人民医院消化内科、南京医科大学无锡医学中心、国家消化系统疾病临床研究中心(西安)江苏省分中心,214023

出　　处：《胃肠病学》2024年第8期490-495,共6页Chinese Journal of Gastroenterology

基　　金：江苏省自然科学基金面上项目(BK20231146);南京医科大学无锡医学中心一般项目(WMCG202326)。

摘　　要：食管和胃肠道恶性肿瘤具有较高的发病率和死亡率,其发生、发展是一个复杂的过程,涉及多种因素。肿瘤相关巨噬细胞(TAM)在食管和胃肠道恶性肿瘤中起有重要作用,可促进肿瘤细胞增殖、侵袭、迁移、耐药,以及肿瘤免疫抑制微环境的形成等。本文就TAM在食管和胃肠道恶性肿瘤中的研究进展作一综述,并对靶向TAM的治疗策略进行总结,包括减少TAM浸润、重编程TAM、嵌合抗原受体巨噬细胞(CAR⁃M)疗法、纳米材料等。Esophageal and gastrointestinal malignancies are associated with high incidence and mortality rates.Their occurrence and development is a complex process of multiple factors.Tumor⁃associated macrophages(TAM)play a vital role in esophageal and gastrointestinal malignancies by promoting tumor cell proliferation,invasion,migration,and drug resistance,as well as by establishing an immunosuppressive microenvironment.This article reviewed the progress of research on TAM in esophageal and gastrointestinal malignancies,and summarized the TAM⁃targeted therapeutic strategies such as reducing TAM infiltration,reprogramming TAM,chimeric antigen receptor⁃macrophage(CAR⁃M)therapy and nanomaterials.

关 键 词：食管肿瘤 胃肠肿瘤 肿瘤相关巨噬细胞 治疗 

分 类 号：R735[医药卫生—肿瘤]