纳米医学介导的铜死亡在乳腺癌治疗中的应用和进展  

Application and progress of nano-medicine mediated cuproptosis in the breast cancer treatment

作　　者：王锐 马得原 贾王强(综述) 关泉林(审校)[1,2] WANG Rui;MA Deyuan;JIA Wangqiang;GUAN Quanlin(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Gastrointestinal Oncology Surgery,First Hospital of Lanzhou University)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院胃肠肿瘤外科

出　　处：《实用肿瘤学杂志》2025年第2期144-150,共7页Practical Oncology Journal

基　　金：国家重点研发计划(编号:2017YFC0908302)。

摘　　要：近10年来,乳腺癌的新发病例和死亡病例均居女性恶性肿瘤首位,且发病率呈上升及年轻化趋势。乳腺癌表现出高度的异质性特征,容易对综合治疗方案产生耐药性。铜死亡作为一种由铜介导的新发现的调节性细胞死亡形式,与乳腺癌的发生发展密切相关。随着纳米医学的进步,以铜为代表的金属药物可通过纳米材料的特异性递送系统定向输送铜离子至肿瘤部位。这些金属药物通过诱导过量铜负荷、调节肿瘤微环境以及增强抗肿瘤免疫应答杀伤肿瘤细胞。因此,在乳腺癌治疗中,铜基纳米药物展现出显著的应用潜力。本文对铜死亡在乳腺癌发生发展中的作用机制及目前纳米医学介导的铜死亡在乳腺癌治疗中的应用及进展进行综述。Over the past decade,the new cases and deaths of breast cancer has rank first among malignant tumors in women,and its incidence is rising,with a younger age trend.Breast cancer demonstrates a high degree of heterogeneity and is prone to drug resistance to comprehensive treatment.As a newly discovered regulatory cell death form mediated by copper,cuproptosis is closely related to the occurrence and development of breast cancer.With the advancement of nano-medicine,metal-based drugs represented by copper can selectively deliver copper ions to tumor sites through the specific delivery system of nanomaterials.These metal drugs kill tumor cells by inducing copper overload,regulating the tumor microenvironment,and enhancing anti-tumor immune response.Therefore,copper-based drugs exhibit significant application potential in the treatment of breast cancer.This article reviews of the mechanism of cuproptosis in the occurrence and development of breast cancer and the application and progress of nanomedicine-mediated cuproptosis in the treatment of breast cancer.

关 键 词：铜死亡 乳腺癌 纳米医学 铜基纳米药物 耐药 

分 类 号：R737.9[医药卫生—肿瘤]