肿瘤坏死因子受体相关因子6血管生成素样蛋白8对短暂性脑缺血发作脑梗死发病风险的预测价值  

Predictive value of TRAF6 and ANGPTL8 in the risk of transient ischemic attack and cerebral infarction

作　　者：张铁山[1] 王冬梅 邢汝月 陈骏 Zhang Tieshan;Wang Dongmei;Xing Ruyue;Chen Jun(Deptartment of Emergency,Affiliated Hospital of Yellow River University of Science and Technology,Zhengzhou 450000,China;不详)

机构地区：[1]河南省黄河科技学院附属医院急诊科,郑州450000 [2]南阳医学高等专科学校第一附属医院神经内科

出　　处：《山西医药杂志》2025年第7期483-487,共5页Shanxi Medical Journal

基　　金：河南省医学科技攻关项目(LHGJ20201215)。

摘　　要：目的分析肿瘤坏死因子受体相关因子6(TRAF6)、血管生成素样蛋白8(ANGPTL8)对短暂性脑缺血发作(TIA)继发脑梗死(CI)的预测价值。方法回顾性分析我院2022年5月至2024年5月102例TIA患者的一般资料,临床资料,依据是否继发CI将其分别列为CI组(22例)和非CI组(80例),归纳TIA患者继发CI的危险因素,分析TRAF6、ANGPTL8对TIA患者继发CI的预测价值。结果CI组的年龄、体质指数(BMI)、合并高血压占比、合并糖尿病占比、合并高脂血症占比、动脉狭窄率、合并颈动脉斑块占比、发病至首次就诊时间、TIA持续时间、TIA发作次数、短暂性脑缺血发作风险评估量表(ABCD2)评分、TRAF6、ANGPTL8均高于非CI组(P<0.05)。BMI指数、动脉狭窄率、合并颈动脉斑块、发病至首次就诊时间、TIA持续时间、TIA发作次数、ABCD2评分、TRAF6、ANGPTL8为TIA继发CI的危险因素。TRAF6、ANGPTL8联合检测对TIA继发CI的预测灵敏度、特异度(83.8%、78.3%)均高于TRAF6单独检测(81.1%、76.7%)、ANGPTL8单独检测(80.2%、71.4%)、曲线下面积(AUC)=0.861、0.854、0.853。结论TRAF6、ANGPTL8高表达为TIA继发CI的危险可控因素,联合检测TRAF6、ANGPTL8变化能实现对CI风险的早期预测。Objective To analyze the predictive value of TRAF6 and ANGPTL8 for secondary cerebral infarction(CI)in transient ischemic attack(TIA).Methods A retrospective analysis was conducted on the general and clinical data of 102 TIA patients in our hospital from May 2022 to May 2024.Based on whether they had secondary CI,they were classified as CI group(22 cases)and non-CI group(80 cases),respectively.The risk factors for secondary CI in TIA patients were summarized,and the predictive value of TRAF6 and ANGPTL8 for secondary CI in TIA patients was analyzed.Results The age,body mass index(BMI),the proportion of hypertension,diabetes,hyperlipidemia,arterial stenosis rate,the proportion of carotid plaque,the time from onset to the first visit,TIA duration,the number of TIA attacks,the risk assessment scale for transient ischemic attack(ABCD2)score,TRAF6,and ANGPTL8 in the CI group were higher than those in the non-CI group.BMI index,arterial stenosis rate,presence of carotid plaques,time from onset to first visit,duration of TIA,number of TIA episodes,ABCD2 score,TRAF6,ANGPTL8 are risk factors for secondary CI in TIA.The combined detection of TRAF6 and ANGPTL8 showed higher sensitivity and specificity(83.8%,78.3%)in predi-cting secondary CI in TIA compared to TRAF6 alone(81.1%,76.7%)and ANGPTL8 alone(80.2%,71.4%),(AUC=0.861,0.854,0.853).Conclusion The high expression of TRAF6 and ANGPTL8 is a controllable risk factor for secondary CI in TIA.Combined detection of changes in TRAF6 and ANGPTL8 can achieve early prediction of CI risk.

关 键 词：脑缺血发作 短暂性 脑梗死 危险因素 受体 肿瘤坏死因子 血管生成素样蛋白8 

分 类 号：R743.3[医药卫生—神经病学与精神病学]