E2A-HLF阳性急性淋巴细胞白血病的临床分析  

A Clinical Study of Acute Lymphoblastic Leukemia with E2A-HLF Fusion Gene

作　　者：吴艳珺 陈峰[1] 吴德沛[1] 蔡成森[1] WU Yan-jun;CHEN Feng;WU De-pei;CAI Cheng-sen(Department of Hematology,First Affiliated Hospital of Soochow University,National Clinical Research Center for Hematologic Diseases,Soochow University,Suzhou,Jiangsu,215006,China)

机构地区：[1]苏州大学附属第一医院血液内科,国家血液系统疾病临床医学研究中心,江苏省血液研究所,江苏苏州215006

出　　处：《中国血液流变学杂志》2024年第4期538-540,571,共4页Chinese Journal of Hemorheology

基　　金：江苏省医学创新中心(CXZX202201)。

摘　　要：目的探索伴有E2A-HLF基因急性淋巴细胞白血病的临床表现、治疗及预后。方法回顾性分析2017年7月—2024年10月就诊于苏州大学附属第一医院的3例伴有E2A-HLF基因急性淋巴细胞白血病患者的临床表现、治疗及转归情况。结果男2例,女1例,中位年龄15.3(10-18)岁。3例患者均在诊断时合并高钙血症,2例患者合并血凝功能异常。2例患者在治疗过程中复发,其中1例患者行CAR-T细胞治疗后骨髓移植长期生存,另1例患者死于本病。3例患者中有2例患者移植后维持缓解状态。结论伴有E2A-HLF基因急性淋巴细胞白血病罕见,多见于儿童及青少年,初诊时常伴有高钙血症及血凝功能障碍,对传统化疗药物不敏感,复发难治患者可考虑新型药物治疗,尽早行造血干细胞移植。Objective To explore the clinical,therapeutic,and prognostic aspects of acute lymphoblastic leukemia associated with the E2A-HLF fusion gene.Methods Three patients with E2A-HLF fusion gene who were treated at the First Affiliated Hospital of Soochow University from July 2017 to October 2024 were reported.Results Two males and one female,with a median age of 15.3(range 10-18)years old.All three patients had hypercalcemia at the time of diagnosis,and two patients had coagulation dysfunction.Two patients relapsed during the treatment.One patient received CAR-T cell therapy followed by bone marrow transplantation and survived,while another patient died.Out of the three patients,two maintained remission status after transplantation.Conclusion Acute lymphoblastic leukemia associated with the E2A-HLF gene is rare and more common in children and adolescents.At diagnosis,it is often accompanied by hypercalcemia and coagulation dysfunction.It is not sensitive to traditional chemotherapy drugs.New drug treatments can be considered,and hematopoietic stem cell transplantation should be performed as early as possible.

关 键 词：E2A-HLF融合基因 白血病 淋巴细胞 

分 类 号：R733.71[医药卫生—肿瘤]