住院监护下口服普萘洛尔对血管瘤患儿心率和血糖的影响  

Effects of oral propranolol on heart rate and blood glucose in children with hemangiomas receiving hospital care

作　　者：黄华旭 陈宣锋 蔡北辰 余佳祺 谢包根 陈健[1] 翁明生 徐志雄 李瑞粦 卢政 黄永新[1] Huang Huaxu;Chen Xuanfeng;Cai Beichen;Yu Jiaqi;Xie Bogen;Chen Jian;Weng Mingsheng;Xu Zhixiong;Li Ruilin;Lu Zheng(Department of Burn and Plastic Surgery,Teaching Hospital of Putian First Hospital,Fujian Medical University,Putian 351100,China;Department of Plastic Surgery,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350000,China)

机构地区：[1]福建医科大学莆田市第一医院教学医院烧伤整形科,莆田351100 [2]福建医科大学附属第一医院整形外科,福州350000

出　　处：《中华医学美学美容杂志》2025年第2期120-125,共6页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：福建省自然科学基金青年项目(2020J05256)。

摘　　要：目的探讨住院监护下口服普萘洛尔对血管瘤患儿心率和血糖的影响。方法回顾性纳入福建医科大学附属第一医院2013年1月至2021年8月住院监护下首次口服普萘洛尔治疗血管瘤的患儿259例,其中男77例,女182例,年龄(125.2±85.4)d,体重(6.3±1.6)kg。患儿空腹,采用每日单次给药、每日同等剂量的给药方式,普萘洛尔的剂量为每天0.5~2.5 mg/kg。所有患儿服药前测量空腹血糖及心率,在服药后2 h再次测量患儿血糖,在服药后的1、3、6 h分别测量患儿心率,连续测量3 d。观察并记录服药后患儿出现的不良反应。结果口服普萘洛尔3 d内,每天服药后1、3、6 h的心率均较用药前降低(均P<0.001)。服药后3 d内,每天服用普萘洛尔2 h后,患儿血糖均降低(均P<0.001)。在患儿住院监护期间,不良反应发生率为5.4%(14/259),包括病灶处溃疡4例、上呼吸道感染伴发热4例、进食减少2例、恶心呕吐1例、精神萎靡1例、窦性心动过速1例、高钾血症1例,未出现危急生命的严重不良反应。结论口服普萘洛尔后,患儿心率及血糖较服药前均有不同程度下降。Objective To investigate the effects of oral propranolol on the heart rate and blood glucose levels in children with hemangiomas receiving hospital care.Methods A total of 259 children[77 males and 182 females,aged(125.2±85.4)days,weighted(6.3±1.6)kg],who were treated with oral propranolol for the first time under hospital care from January 2013 to August 2021,were retrospectively analyzed.After fasting,the patients administered the same dose of propranolol once daily(0.5-2.5 mg/kg).Fasting blood glucose and heart rate were measured in all children before propranolol administration and after 2 h.Heart rate was measured at 1,3 and 6 h after propranolol administration for three consecutive days.Adverse reactions were observed and recorded.Results Within three days of oral propranolol administration,the heart rates at 1,3 and 6 h after propranolol administration were lower than those before propranolol administration(all P<0.001).Within three days after taking propranolol and 2 h after taking propranolol daily,blood glucose levels reduced in all children(all P<0.001).During the hospitalization period,the incidence of adverse reactions was 5.4%(14/259),including lesion ulcers in four cases,upper respiratory tract infection with fever in four,reduced eating in two,nausea and vomiting in one,lethargy in one,sinus tachycardia in one,and hyperkalemia in one.No serious adverse reactions were life-threatening.Conclusion After oral administration of propranolol,the heart rate and blood sugar of the children decrease to different degrees compared with those before propranolol administration.

关 键 词：普萘洛尔 婴幼儿血管瘤 住院监护 心率 血糖 不良反应 

分 类 号：R732.2[医药卫生—肿瘤]