Threshold-Effect Associations of Serum 25- hydroxyvitamin D on Bone Turnover Markers and GC rs2282679 Variants in Chinese Women of Childbearing Age  

作　　者：Xiaoyun Shan Yuting Li Xiayu Zhao Yichun Hu Siran Li Huidi Zhang Yang Cao Rui Wang Lichen Yang 

机构地区：[1]Key Laboratory of Public Nutrition and Health,National Health Commission of the People's Republic of China,National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China [2]Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards,School of Public Health,Hengyang Medical School,University of South China,Hengyang 241001,Hunan,China

出　　处：《Biomedical and Environmental Sciences》2025年第4期433-446,共14页生物医学与环境科学(英文版)

摘　　要：Objective This study aimed to investigate possible serum 25-hydroxyvitamin D[25(OH)D]cutoffs for the associations between 25(OH)D and Bone turnover markers(BTMs),and how GC gene variation influences such cutoffs in Chinese women of childbearing age.Methods In total,1,505 non-pregnant or non-lactating women(18–45 years)were recruited from the 2015 Chinese Adult Chronic Disease and Nutrition Surveillance.Serum 25(OH)D,osteocalcin(OC),procollagen type 1 N-terminal propeptide(P1NP),β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide(β-CTX),and single nucleotide polymorphisms were determined.Locally weighted regression and smoothing scatterplot and segmented regression were performed to estimate the 25(OH)D thresholds.Results The median serum 25(OH)D was 16.63(11.96–22.55)ng/mL and the prevalence of low serum 25(OH)D(<12 ng/mL)was 25.2%.Women with the lowest 25(OH)D had the highestβ-CTX.After adjustment for the confounders,25(OH)D cutoffs for OC[14.04(12.84–15.23)ng/mL],β-CTX[13.94(12.49–15.39)ng/mL],and P1NP[13.87(12.37–15.37)ng/mL]in the whole population,cutoffs for OC[12.30(10.68–13.91)ng/mL],β-CTX[12.23(10.22–14.23)ng/mL],and P1NP[11.85(10.40–13.31)ng/mL]in women with the GC rs2282679 G allele,and cutoffs for OC[12.75(11.81–13.68)ng/mL],β-CTX[13.05(11.78–14.32)ng/mL],and P1NP[12.81(11.57–14.06)ng/mL]in women with the GC rs2282679 T allele,were observed.Below these cutoffs,BTMs were negatively associated with 25(OH)D,while above these cutoffs,BTMs plateaued.Conclusion In Chinese women of childbearing age,there were thresholds effect of serum 25(OH)D concentrations on BTMs.The results indicated that serum 25(OH)D concentrations<13.87 ng/mL in this population had adverse influences on maintaining bone remodeling.BTMs were suppressed at a relatively lower serum 25(OH)D in women with the GC rs2282679 G allele compared with those with the T allele.

关 键 词：25-hydroxyvitamin D OSTEOCALCIN Procollagen type 1 N-terminal propeptide β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide Gene polymorphism 

分 类 号：R589.5[医药卫生—内分泌]