高级别子宫内膜间质肉瘤的病理诊断及分子生物学研究进展  

Advances in pathological diagnosis and molecular characteristics of high-grade endometrial stromal sarcoma

作　　者：师晓华[1] Shi Xiaohua(Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院病理科,北京100730

出　　处：《临床与实验病理学杂志》2025年第4期427-431,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：高级别子宫内膜间质肉瘤是危害女性生殖健康的恶性肿瘤之一,虽然相对罕见,但恶性程度高,患者临床预后差。该病变病理形态学多样、免疫表型缺乏特异性、基因变异形式多样,导致该疾病明确诊断困难,因此,准确识别并诊断该类病变具有挑战性。该文旨在总结该类疾病的临床病理学特征、分子特征及鉴别诊断要点,以期提高对此病变的进一步认识。High-grade endometrial stromal sarcoma(HGESS)is a rare but highly aggressive malignant tumor that poses a significant threat to women’s reproductive health.It is associated with a poor clinical prognosis due to its high malignancy.HGESS exhibits diverse pathological morphologies,lacks specific immunohistochemical markers,and demonstrates various genetic alterations.These factors contribute to the challenges in achieving a definitive diagnosis,making accurate identification and diagnosis of this lesion particularly difficult.This article reviews the clinicopathological features,molecular characteristics,and key points for differential diagnosis of HGESS,aiming to enhance understanding and awareness of this disease among clinicians and pathologists.

关 键 词：高级别子宫内膜间质肉瘤 基因重排 YWHAE-NUTM2A/2B ZC3H7B-BCOR BCOR ITD 

分 类 号：R737.33[医药卫生—肿瘤]