内镜超声引导下穿刺活检术联合多组学在胰腺癌精准诊疗中的应用  

Application of endoscopic ultrasound-guided fine-needle aspiration/biopsy combined with multi-omics in precision diagnosis and treatment of pancreatic ductal adenocarcinoma

作　　者：赵一舟 张尧 张玲 Zhao Yizhou;Zhang Yao;Zhang Ling(Department of Gastroenterology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院消化内科,上海200025

出　　处：《中华胰腺病杂志》2025年第2期85-89,共5页Chinese Journal of Pancreatology

基　　金：国家自然科学基金(82270667)。

摘　　要：内镜超声引导下穿刺活检技术突破了传统胰腺癌研究对外科样本的依赖,使得大量既往难以手术患者的肿瘤原位组织得以微创获取和评估。本文系统性论述内镜超声引导下穿刺活检技术联合多组学技术在胰腺癌精准诊疗中的应用现状,探讨其如何发挥微创和动态追踪的优势,联合多组学技术解析肿瘤微环境动态演变及耐药机制指导临床决策,并展望未来转化研究方向。Endoscopic ultrasound-guided fine-needle aspiration/biopsy(EUS-FNA/B)has overcome the reliance on surgical specimens in traditional pancreatic ductal adenocarcinoma(PDAC)research,enabling minimally invasive acquisition and evaluation of in situ tumor tissues from a large number of patients previously ineligible for surgery.This article systematically discusses the current applications of EUS-FNA/B combined with multi-omics technologies in the precision diagnosis and treatment of pancreatic cancer.We explores how this approach leverages its advantages of minimally invasive sampling and dynamic monitoring to integrate multi-omics analyses,thereby deciphering the dynamic evolution of the tumor microenvironment and drug resistance mechanisms to guide clinical decision-making.Finally,the review highlights future translational research directions aimed at optimizing therapeutic strategies and improving patient outcomes.

关 键 词：胰腺肿瘤 腔内超声检查 内镜超声引导细针穿刺 基因组学 转录组学 精准医疗 

分 类 号：R735.9[医药卫生—肿瘤]