F-53B的生物积累、毒性效应及作用机制研究进展  

Research Progress on Bioaccumulation,Toxic Effects and Mechanism of F-53B on Organisms

作　　者：李迪 范文宏 王兴 杨艳 李晓敏 王颖 LI Di;FAN Wenhong;WANG Xing;YANG Yan;LI Xiaomin;WANG Ying(School of Materials Science and Engineering,Beihang University,Beijing 100191,China;Institute of Resources and Environment,Beijing Academy of Science and Technology,Beijing 100089,China)

机构地区：[1]北京航空航天大学材料科学与工程学院,北京100191 [2]北京市科学技术研究院资源环境研究所,北京100089

出　　处：《生态毒理学报》2025年第2期41-61,共21页Asian Journal of Ecotoxicology

基　　金：国家重点研发计划青年科学家项目(2022YFC3204800)。

摘　　要：氯化多氟醚磺酸盐(6:2 chlorinated polyfluorinated ether sulfonate,商品名F-53B)作为一种新型的全氟辛烷磺酸(perfluoro-octane sulfonate,PFOS)替代物,因其在工业中的大范围应用而受到广泛关注。近期的研究表明,F-53B可能对生态系统和人类健康产生潜在风险。本文综述了F-53B在不同生物体内的吸收与积累,F-53B在生物体内的代谢转化和其对生物的毒性效应及作用机制,结果发现在国内外多个地区的水生、陆生生物中,F-53B的检出浓度存在显著差异。由于F-53B的高亲脂性,使其更多地积累在生物体的肝脏、肾脏等器官中。人体血清中的F-53B检出量最高,尤其是在工业发达地区的工人体内。进一步地,由于厌氧微生物还原脱氯、谷胱甘肽转移酶以及硝酸盐还原酶的作用,F-53B在生物体内能够代谢为6:2 H-PFESA,但转化并不高效。此外,F-53B对生物体的肝脏、肠道、心脏等器官具有显著的毒性效应,其作用机制主要为干扰内分泌、诱导氧化应激、诱导基因毒性和抑制免疫系统作用等。最后,本文对F-53B的未来研究方向提出了建议,并强调了进一步深入研究该化合物毒性效应和作用机制的紧迫性和必要性。研究结果揭示了F-53B潜在的环境持久性和生物累积性,为未来F-53B生态风险的准确评估和污染管控提供科学依据。Chlorinated polyfluorinated ether sulfonate(6:2 chlorinated polyfluorinated ether sulfonate,marketed as F-53B),a novel substitute for perfluorooctane sulfonate(PFOS),has garnered considerable attention due to its extensive industrial application.Recent studies indicate that F53B may pose potential risks to both ecosystems and human health.This review examines the absorption and accumulation of F-53B in various organisms,its metabolic transformation,as well as its toxicological effects and underlying mechanisms.The findings reveal marked regional differences in the concentrations of F-53B detected in aquatic and terrestrial species.Owing to its high lipophilicity,F-53B preferentially accumulates in organs such as the liver and kidneys,with the highest levels observed in human serum—especially among industrial workers in developed regions.Furthermore,due to the action of anaerobic m icrobial dechlorination,glutathione S-transferase,and nitrate reductase,F-53B can be metabolized into 6:2 H-PFESA within organisms,although the conversion efficiency remains low.Additionally,F-53B exhibits s ignificant toxicity towards organs including the liver,intestines,and heart,primarily through mechanisms involving endocrine disruption,induction of oxidative stress,genotoxicity,and immunosuppression.Finally,this paper p roposes recommendations for future research directions and underscores the urgency of further investigations into the toxic effects and mechanisms of F-53B.The results highlight the compound’s potential environmental p ersistence and bioaccumulative properties,thereby providing a scientific basis for accurate ecological risk a ssessment and e ffective pollution control strategies.

关 键 词：F-53B 生物积累 毒性效应 作用机制 PFOS 

分 类 号：X171.5[环境科学与工程—环境科学]