急性胰腺炎中的肝肠对话  

Phenomenon of liver-intestinal dialogue in acute pancreatitis

作　　者：张青 龚淞楠 陈平 ZHANG Qing;GONG Songnan;CHEN Ping(Department of Gastroenterology,Loujiang New City Hospital,Taicang City,Taicang 215400;Department of Gastroenterology,Ruijin Hospital North,Shanghai Jiao Tong University School of Medicine,China)

机构地区：[1]太仓市娄江新城医院消化内科,江苏太仓215400 [2]上海交通大学医学院附属瑞金医院(北院)消化内科

出　　处：《胃肠病学和肝病学杂志》2025年第4期469-471,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：急性胰腺炎(acute pancreatitis,AP)是指因胰酶异常激活对胰腺自身及周围器官产生消化作用而引起的、以胰腺局部炎性反应为主要特征,甚至可导致器官功能障碍的急腹症。肠道通透性的增加和微生态紊乱可加重AP的炎症,肝损伤也与AP的严重程度呈正相关,肠道和肝脏可通过胆道、门静脉和体循环进行沟通,因此提出注重肝肠对话的现象,矫正肠-肝轴紊乱是预防AP疾病进展的一个重要途径,因此本文就AP的肝损伤与肠道功能紊乱的相互影响进行综述,以期指导临床及基础研究。Acute pancreatitis(AP)is emergency caused by the abnormal activation of pancreatic enzymes,which leads to local inflammatory reactions in the pancreas and causes digestive effects on the pancreas and surrounding organs.Increased intestinal permeability and dysbiosis can exacerbate inflammation of AP,and liver injury is positively correlated with the severity of AP.The intestine and liver communicate through the biliary tract,portal vein and systemic circulation,promoting the need to focus on the phenomenon of liver-intestinal dialogue.Correcting disturbances in the gut-liver axis is an important way for preventing the progression of AP.Therefore,this paper reviewed the mutual influence between liver injury and intestinal dysfunction in AP,aiming to provide guidance for clinical and basic research.

关 键 词：急性胰腺炎 肝损伤 肠道屏障功能 肠道微生态 

分 类 号：R576[医药卫生—消化系统]