炎症性肠病潜在的治疗方法及其作用机制研究进展  

Advances in the study of potential therapeutic modalities for inflammatory bowel disease and their mechanisms of action

作　　者：郭昭 庄浩岩 史学文[2] GUO Zhao;ZHUANG Haoyan;SHI Xuewen(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Ji′nan 250014;Department of Anorectal,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250014 [2]山东中医药大学附属医院肛肠科

出　　处：《胃肠病学和肝病学杂志》2025年第4期590-594,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：山东省中医药科技发展项目(2019-0187);齐鲁中医药优势专科集群建设项目(YWC2022ZKJQ0003)。

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是一种慢性、进行性、免疫介导的肠道疾病,目前尚无治愈方法,且发病机制尚不明确。近年来不断探索IBD潜在治疗方式,随着精准医学的不断进步,从损伤细胞再生、肠道黏膜及屏障修复、肠道微生物及其代谢产物、药物递送系统等方面探索IBD治疗的新方向成为国际热点,将弥补目前治疗方案的不足,为患者提供更多选择。目前潜在治疗方式尚未在作用机制、使用规范、安全性、疗效评价等方面达成共识,有待进一步研究,本文就目前IBD的潜在治疗方式及其作用机制研究进展作一综述。Inflammatory bowel disease(IBD)is a chronic,progressive,immune-mediated intestinal disease for which there is no cure and the pathogenesis is unclear.In recent years,potential treatment modalities for IBD have been continuously explored.With the continuous progress of precision medicine,it has become an international hotspot to explore new directions of IBD treatment in terms of regeneration of damaged cells,repair of intestinal mucosa and barrier,intestinal microorganisms and their metabolites,and drug delivery systems,which will make up for the shortcomings of the current treatment options and provide more choices for patients.At present,the potential therapeutic modalities have not yet reached a consensus on the mechanism of action,standardization of use,safety,efficacy evaluation,etc.,and need to be further researched.This article reviewed the current potential therapeutic modalities and their mechanism of action in IBD.

关 键 词：炎症性肠病 潜在治疗方式 黏膜修复 肠道屏障 

分 类 号：R574.62[医药卫生—消化系统]