乳糜泻与小肠细菌过度生长的研究进展  

Research progress on coeliac disease and small intestinal bacterial overgrowth

作　　者：刘卓淑怡 冯燕[2] 高峰[2] LIU Zhuoshuyi;FENG Yan;GAO Feng(Xinjiang Medical University,Urumqi 830000;Department of Gastroenterology,Xinjiang Uygur Autonomous Region People′s Hospital,China)

机构地区：[1]新疆医科大学,新疆乌鲁木齐830000 [2]新疆维吾尔自治区人民医院消化科

出　　处：《胃肠病学和肝病学杂志》2025年第4期595-598,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金项目(82260116)。

摘　　要：乳糜泻(coeliac disease,CeD)是一种自身免疫性疾病,主要临床表现有腹痛、腹胀、腹泻、胃肠胀气、维生素缺乏、营养吸收不良等症状。CeD的发病机制多与麸质摄入、遗传以及肠道微生物相关。肠道微生物在CeD中的作用受到越来越多关注,肠道菌群失调可以改变胃肠道生理功能,从而影响肠道通透性、胃肠动力、肠道免疫系统等。小肠细菌过度生长(small intestinal bacterial overgrowth,SIBO)是一种常见的肠道菌群紊乱综合征,但是目前对于CeD中SIBO的认识尚不足,本文从SIBO的发病机制、临床意义及其与CeD的关系等方面进行综述。Coeliac disease(CeD)is an autoimmune disorder characterized by abdominal pain,bloating,diarrhea,gastrointestinal distension,vitamin deficiency,and poor nutrient absorption.The pathogenesis of CeD is related to gluten intake,genetic factors,and intestinal microbiota.The role of intestinal microbiota in CeD is increasingly recognized,as dysbiosis of the gut microbiota can alter the gastrointestinal physiological function,thereby affecting intestinal permeability,gastrointestinal motility,and intestinal immune system.Small intestinal bacterial overgrowth(SIBO)is a common syndrome of gut microbiota dysbiosis,but there is currently a lack of understanding of the relationship between SIBO and CeD.This review summarized the pathogenesis,clinical significance,and relationship between SIBO and CeD.

关 键 词：小肠细菌过度生长 乳糜泻 肠道菌群 氢气甲烷呼气试验 

分 类 号：R57[医药卫生—消化系统]