巨噬细胞与自身免疫性肝炎的关系研究进展  

Research progress on the relationship between macrophages and autoimmune hepatitis

作　　者：张佳庆 任鑫瑶 寇静薇 李慧 王倩辰 万鹏 孟杰[1] 王阳阳[1] ZHANG Jiaqing;REN Xinyao;KOU Jingwei;LI Hui;WANG Qianchen;WAN Peng;MENG Jie;WANG Yangyang(Department of Gastroenterology,Affiliated Hospital of Hebei University,Baoding 071000;School of Clinical Medicine,Hebei University,China)

机构地区：[1]河北大学附属医院消化内科,河北保定071000 [2]河北大学临床医学院

出　　处：《胃肠病学和肝病学杂志》2025年第4期605-608,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：2023年河北省自然科学基金面上项目(H2023201022);2022年政府资助临床医学优秀人才培养项目(361007)。

摘　　要：自身免疫性肝炎(autoimmune hepatitis,AIH)的发病与遗传、病毒及药物等外源性因素、免疫调节紊乱等机制相关。肝内巨噬细胞可以通过吞噬、处理和呈递抗原、释放炎症因子来实现其免疫调节的功能。在AIH的发病过程中,肝内巨噬细胞吞噬呈递功能下降、启动招募作用从而增加自身数量、向促炎表型极化而发挥促进肝内炎症进展的作用。The pathogenesis of autoimmune hepatitis(AIH)is related to exogenous factors such as genetics viruses and drugs,and immune regulation disorders.Intrahepatic macrophages can achieve their immunomodulatory functions by phagocytosis,processing and presenting antigens,and releasing inflammatory cytokines.During the pathogenesis of AIH,intrahepatic macrophages decreased phagocytosis presentation,initiated recruitment to increase their own number,polarized to the pro-inflammatory phenotype,and played a role in promoting the progression of intrahepatic inflammation.

关 键 词：自身免疫性肝炎 巨噬细胞 库普弗细胞 巨噬细胞极化 

分 类 号：R575[医药卫生—消化系统]