阴道微生态与宫颈病变发生发展的相关性研究进展  

Research progress on the correlation between vaginal microbiota and the occurrence and development of cervical lesions

作　　者：梁超 安月盘 李筱贺 乌音嘎 刘巍 LIANG Chao;AN Yuepan;LI Xiaohe;WU Yinga;LIU Wei(Graduate School,Inner Mongolia Medical University,Inner Mongolia,Hohhot 010000,China;Department of Gynecology,Maternal and Child Health Hospital of Inner Mongolia Autonomous Region,Inner Mongolia,Hohhot 010000,China;School of Basic Medical Sciences,Inner Mongolia Medical University,Inner Mongolia,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学研究生学院,内蒙古呼和浩特010000 [2]内蒙古自治区妇幼保健院妇科,内蒙古呼和浩特010000 [3]内蒙古医科大学基础医学院,内蒙古呼和浩特010000

出　　处：《中国医药科学》2025年第7期31-34,共4页China Medicine And Pharmacy

基　　金：内蒙古自治区科技计划项目(2023YFSH0008);公立医院科研联合基金科技项目(2024GLLH0191)。

摘　　要：宫颈癌是全球女性最常见的恶性肿瘤之一,宫颈病变的发展过程通常从慢性宫颈炎逐渐演变为子宫颈上皮内病变,最终发展为宫颈癌。持续性高危型人乳头瘤病毒感染被认为是子宫颈上皮内病变发生发展的主要生物学原因,而阴道微生态的平衡状态也与之紧密相关。近年来研究显示,阴道微生态失衡可能导致阴道上皮损伤并引发相关炎症反应,从而增加人乳头瘤病毒感染的风险,进一步加剧宫颈病变。不同程度的宫颈病变能改变阴道生物群落的数量和种类,从而打破微生态平衡,二者之间由此形成恶性循环。本文拟对近年来阴道微生态与宫颈病变发生发展相关性的研究进行总结分析,以期为宫颈癌的预防、早期诊断和治疗提供新的思路和理论依据。Cervical cancer is one of the most common malignant tumors among women worldwide.The progression of cervical lesions typically follows a sequence from chronic cervicitis to cervical intraepithelial neoplasia and ultimately to cervical cancer.Persistent infection with high-risk human papillomavirus is considered the primary biological cause of the development and progression of cervical intraepithelial neoplasia,and the balance of the vaginal microbiome is closely related to this process.Recent studies have shown that vaginal microecological imbalance may lead to vaginal epithelial damage and trigger related inflammatory responses,thereby increasing the risk of human papilloma virus infection and further exacerbating the progression of cervical lesions.Additionally,varying degrees of cervical lesions can alter the quantity and composition of vaginal microbial communities,disrupting the microecological balance.This creates a vicious cycle between the two.This article aims to summarize and analyze recent research on the correlation between vaginal microecology and the development and progression of cervical lesions,with the goal of providing new insights and theoretical foundations for the prevention,early diagnosis,and treatment of cervical cancer.

关 键 词：阴道微生态 高危型人乳头瘤病毒 宫颈病变 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]