泮托拉唑、克拉霉素、阿莫西林与果胶铋四联疗法不同疗程治疗胃溃疡临床疗效的比较研究  

Comparative Study on the Clinical Efficacy of Pantoprazole,Clarithromycin,Amoxicillin and Bismuth Pectin Quadruple Therapy with Different Courses in the Treatment of Gastric Ulcer

作　　者：李桃 LI Tao(Department of Gastroenterology,Xinfeng County Hospital of Traditional Chinese Medicine,Xinfeng 341600,Jiangxi,China)

机构地区：[1]信丰县中医院消化内科,江西信丰341600

出　　处：《医学信息》2025年第9期121-124,共4页Journal of Medical Information

摘　　要：目的探究不同疗程的四联疗法(泮托拉唑+克拉霉素+阿莫西林+果胶铋)治疗胃溃疡的临床效果。方法选取2020年11月-2023年11月信丰县中医院收治的68例胃溃疡患者,经随机数字表法分为常规组(34例)与延长组(34例)。两组均采用四联疗法(泮托拉唑+克拉霉素+阿莫西林+果胶铋),常规组治疗时长2周,延长组在其基础上延长泮托拉唑与果胶铋的用药时长1周,比较两组临床疗效、症状变化(胃灼烧痛、腹胀、恶心)、胃溃疡愈合时间、不良反应、复发情况(治疗后3个月)。结果延长组治疗有效率高于常规组(P<0.05)。两组治疗后症状积分(胃灼烧痛、腹胀、恶心)低于治疗前,且延长组症状积分(胃灼烧痛、腹胀、恶心)低于常规组(P<0.05)。延长组胃溃疡愈合时间短于常规组,复发率低于常规组(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论四联疗法(泮托拉唑+克拉霉素+阿莫西林+果胶铋)治疗胃溃疡效果确切,在常规疗程基础上延长泮托拉唑与果胶铋治疗时长,可提高其临床疗效,促进症状改善,加速病情转归,降低胃溃疡的复发风险,且不增加患者的不良反应。Objective To explore the clinical effect of different courses of quadruple therapy(pantoprazole+clarithromycin+amoxicillin+bismuth pectin)in the treatment of gastric ulcer.Methods A total of 68 patients with gastric ulcer admitted to Xinfeng County Hospital of Traditional Chinese Medicine from November 2020 to November 2023 were selected and divided into routine group(34 patients)and prolonged group(34 patients)by random number table method.Both groups were treated with quadruple therapy(pantoprazole+clarithromycin+amoxicillin+bismuth pectin).The conventional group was treated for 2 weeks,and on the basis of the conventional group,the extension group extended the duration of pantoprazole and bismuth pectin for 1 week.The medication time of pantoprazole and bismuth pectin was 1 week.The clinical efficacy,symptom changes(heartburn,abdominal distension,nausea),gastric ulcer healing time,adverse reactions,and recurrence(3 months after treatment)were compared between the two groups.Results The effective rate of treatment in the extended group was higher than that in the conventional group(P<0.05).After treatment,the symptom scores(heartburn,abdominal distension,nausea)of the two groups were lower than those before treatment,and the symptom scores(heartburn,abdominal distension,nausea)of the extended group were lower than those of the conventional group(P<0.05).The gastric ulcer healing time in the extended group was shorter than that in the conventional group,and the recurrence rate was lower than that in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Quadruple therapy(pantoprazole+clarithromycin+amoxicillin+bismuth pectin)is effective in the treatment of gastric ulcer.Prolonging the treatment time of pantoprazole and bismuth pectin on the basis of routine treatment can improve its clinical efficacy,promote the improvement of symptoms,accelerate the outcome of the disease,reduce the risk of recurrence of gastric ulcer,a

关 键 词：胃溃疡 四联疗法 泮托拉唑 克拉霉素 阿莫西林 果胶铋 

分 类 号：R573.1[医药卫生—消化系统]