尤瑞克林治疗脑梗死的效果及对血清学炎症因子、神经功能恢复、生活质量的影响  

Effect of Urinary Kallidinogenase in the Treatment of Cerebral Infarction and its Influence on Serological Inflammatory Factors,Neurological Function Recovery and Quality of Life

作　　者：周卫凤 ZHOU Weifeng(Department of Pharmacy,Shangrao Guangfeng District People's Hospital,Shangrao 334600,Jiangxi,China)

机构地区：[1]上饶市广丰区人民医院药剂科,江西上饶334600

出　　处：《医学信息》2025年第9期129-132,共4页Journal of Medical Information

摘　　要：目的评价尤瑞克林治疗脑梗死的临床效果及对患者血清学炎症因子、神经功能恢复、生活质量的影响。方法选择2020年1月-2023年12月上饶市广丰区人民医院收治的60例脑梗死患者作为研究对象,按照随机数字表法将其分为对照组和研究组,每组30例。对照组采用常规治疗,研究组在其基础上采用尤瑞克林治疗。比较两组临床疗效、血清学炎症因子[血清C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、神经功能(NIHSS评分、CSS评分)、生活质量(躯体功能、生理功能、社会功能、情感功能)。结果与对照组治疗总有效率的73.33%比较,研究组治疗总有效率更高,为96.67%(P<0.05)。两组治疗后血清炎症因子水平(CRP、IL-6)低于治疗前,且与对照组比较,研究组治疗后血清炎症因子水平(CRP、IL-6)更低(P<0.05);两组治疗后NIHSS评分、CSS评分低于治疗前,躯体功能、生理功能、社会功能及情感功能评分均高于治疗前,且与对照组比较,研究组治疗后NIHSS评分、CSS评分更低,躯体功能、生理功能、社会功能及情感功能评分更高(P<0.05)。结论尤瑞克林可提升脑梗死患者的临床疗效,改善患者炎性反应,提高患者生活质量和神经功能,值得临床应用。Objective To evaluate the clinical effect of urinary kallidinogenase in the treatment of cerebral infarction and its effect on serum inflammatory factors,neurological function recovery and quality of life.Methods A total of 60 patients with cerebral infarction admitted to Shangrao Guangfeng District People's Hospital from January 2020 to December 2023 were selected as the research objects,and they were divided into control group and study group according to the random number table method,with 30 patients in each group.The control group was treated with routine treatment,and the study group was treated with urinary kallidinogenase on the basis of routine treatment.The clinical efficacy,serum inflammatory factors[serum C-reactive protein(CRP),interleukin-6(IL-6)]levels,neurological function(NIHSS score,CSS score),quality of life(physical function,physiological function,social function,emotional function)were compared between the two groups.Results Compared with 73.33%of the total effective rate of the control group,the total effective rate of the study group was higher,which was 96.67%(P<0.05).The levels of serum inflammatory factors(CRP,IL-6)in the two groups after treatment were lower than those before treatment,and compared with the control group,the levels of serum inflammatory factors(CRP,IL-6)in the study group after treatment were lower(P<0.05).The NIHSS score and CSS score of the two groups after treatment were lower than those before treatment,the scores of physical function,physiological function,social function and emotional function were higher than those before treatment,and compared with the control group,the NIHSS score and CSS score of the study group after treatment were lower,and the scores of physical function,physiological function,social function and emotional function were higher(P<0.05).Conclusion Urinary kallidinogenase can improve the clinical efficacy of patients with cerebral infarction,improve the inflammatory response,improve the quality of life and neurological function of patients,whi

关 键 词：尤瑞克林 脑梗死 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]