超声检测胎儿颈项透明层厚度联合血清孕酮及促甲状腺素检测对胎儿产前诊断和妊娠结局的预测价值  

Predictive Value of Ultrasound Detection of Fetal Nuchal Translucency Thickness Combined with Serum Progesterone and Thyrotropin Detection for Fetal Prenatal Diagnosis and Pregnancy Outcome

作　　者：谢小英 邓子强 刘志红 XIE Xiaoying;DENG Ziqiang;LIU Zhihong(Department of Obstetrics and Gynecology,Xingguo County Traditional ChineseMedicine Hospital,Xingguo 342400,Jiangxi,China;Department of Functional,Xingguo County Traditional ChineseMedicine Hospital,Xingguo 342400,Jiangxi,China)

机构地区：[1]兴国县中医院产科,江西兴国342400 [2]兴国县中医院功能科,江西兴国342400

出　　处：《医学信息》2025年第9期158-161,共4页Journal of Medical Information

摘　　要：目的探讨超声检测胎儿颈项透明层厚度(NT)联合血清孕酮(PROG)及促甲状腺素(TSH)检测对胎儿产前诊断和妊娠结局的预测价值。方法选取兴国县中医院2022年1月-2023年12月收治的孕早期胎儿染色体异常孕妇62例作为研究组,另选取同期胎儿发育正常孕妇62例为对照组。比较两组孕妇以及研究组组内不同妊娠结局孕妇血清PROG、TSH水平及NT值,分析NT值、PROG、TSH三者单独及联合检查的诊断效能。结果研究组PROG水平低于对照组,且TSH水平及NT值高于对照组(P<0.05);研究组62例孕妇中,妊娠结局良好41例,不良妊娠结局21例。妊娠结局不良孕妇PROG水平低于妊娠结局良好孕妇,且TSH水平及NT值高于妊娠结局良好孕妇(P<0.05)。NT值、PROG、TSH三者联合预测妊娠结局的灵敏度高于NT值、PROG、TSH三者单独检测(P<0.05)。结论超声检测胎儿颈项透明层厚度联合血清孕酮及促甲状腺素检测在胎儿产前诊断和妊娠结局预测中的价值确切,值得临床应用。Objective To investigate the predictive value of ultrasound detection of fetal nuchal translucency thickness(NT)combined with serum progesterone(PROG)and thyrotropin(TSH)in prenatal diagnosis and pregnancy outcome.Methods A total of 62 pregnant women with fetal chromosomal abnormalities in early pregnancy admitted to Xingguo County Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were selected as the study group,and 62 pregnant women with normal fetal development during the same period were selected as the control group.The serum PROG,TSH levels and NT values of pregnant women in the two groups and pregnant women with different pregnancy outcomes in the study group were compared,and the diagnostic efficacy of NT value,PROG and TSH alone and in combination was analyzed.Results The PROG level of the study group was lower than that of the control group,and the TSH level and NT value were higher than those of the control group(P<0.05).Among the 62 pregnant women in the study group,41 had good pregnancy outcomes and 21 had adverse pregnancy outcomes.The PROG level of pregnant women with poor pregnancy outcome was lower than that of pregnant women with good pregnancy outcome,and the TSH level and NT value were higher than those of pregnant women with good pregnancy outcome(P<0.05).The sensitivity of NT value,PROG and TSH combined to predict pregnancy outcome was higher than that of NT value,PROG and TSH alone(P<0.05).Conclusion Ultrasound detection of fetal nuchal translucency thickness combined with serum progesterone and thyrotropin detection is of great value in prenatal diagnosis and pregnancy outcome prediction,which is worthy of clinical application.

关 键 词：超声检测 胎儿颈项透明层厚度 血清孕酮 促甲状腺素 产前诊断 妊娠结局 

分 类 号：R714.5[医药卫生—妇产科学]