左乙拉西坦治疗小儿癫痫的临床效果  

Clinical effect of Levetiracetam in the treatment of pediatric epilepsy

作　　者：侯雪雪 杨勇[1] HOU Xuexue;YANG Yong(Department of Pediatrics,the First People’s Hospital of Changzhou,Jiangsu Province,Changzhou 213000,China)

机构地区：[1]江苏省常州市第一人民医院儿科,江苏常州213000

出　　处：《妇儿健康导刊》2025年第8期115-118,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨左乙拉西坦治疗小儿癫痫的临床效果。方法选取2022年7月至2024年7月常州市第一人民医院收治的130例癫痫患儿,依照随机数字表法分为观察组(n=65,口服左乙拉西坦治疗)与对照组(n=65,口服丙戊酸钠缓释片治疗)。比较两组临床疗效、认知功能[韦氏儿童智力量表(WLSC-CR)评分]及不良反应发生情况。结果观察组治疗总有效率(95.38%)较对照组(84.62%)高,差异有统计学意义(P<0.05)。治疗后,观察组WLSC-CR评分中的语言智商[(49.45±1.32)分]、操作智商[(49.22±1.32)分]、总智商[(99.55±1.45)分]评分高于对照组[(48.13±1.35)、(48.74±1.38)、(98.21±1.53)分],差异有统计学意义(P<0.05)。观察组不良反应总发生率(6.15%)低于对照组(16.92%),差异有统计学意义(P<0.05)。结论小儿癫痫采用左乙拉西坦治疗的临床效果较好,可改善患儿认知功能,减少不良反应。Objective To explore the clinical effect of L evetiracetam in the treatment of pediatric epilepsy.Methods A total of 130 children with epilepsy admitted to the First People’s Hospital of Changzhou from July 2022 to July 2024 were selected and divided into the observation group(n=65,treated with oral Levetiracetam)and the control group(n=65,treated with oral Sodium Valproate Sustained-release Tablets)according to the random number table.The clinical efficacy,cognitive function(Wechsler intelligence scale for children[WLSC-CR]score),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(95.38%)was higher than that in the control group(84.62%),and the difference was statistically significant(P<0.05).After treatment,the verbal intelligence quotient([49.45±1.32]points),performance intelligence quotient([49.22±1.32]points),and total intelligence quotient([99.55±1.45]points)scores in the WLSC-CR score of the observation group were higher than those of the control group([48.13±1.35],[48.74±1.38],and[98.21±1.53]points),and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group(6.15%)was lower than that in the control group(16.92%),and the difference was statistically significant(P<0.05).Conclusion The clinical effect of Levetiracetam in the treatment of pediatric epilepsy is good,which can improve cognitive function and reduce adverse r eactions.

关 键 词：左乙拉西坦 小儿癫痫 认知功能 不良反应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]