益生菌联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床效果  

Clinical effect of probiotics combined with mesalazine in the treatment of mild to moderate ulcerative colitis

作　　者：乔小梅 QIAO Xiaomei(Digestive Medicine Department,Shenmu Hospital,Shenmu 719300,China)

机构地区：[1]神木市医院消化内科,陕西神木719300

出　　处：《临床医学研究与实践》2025年第12期58-61,共4页Clinical Research and Practice

摘　　要：目的探讨益生菌联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床效果。方法选取2022年3月至2023年3月我院收治的98例轻中度溃疡性结肠炎患者为研究对象,根据治疗方案的不同将其分为对照组和观察组,各49例。对照组给予美沙拉嗪治疗,观察组在对照组基础上加用益生菌治疗。比较两组的治疗效果。结果治疗后,观察组的改良Mayo、溃疡性结肠炎内镜下严重程度指数(UCEIS)评分低于对照组(P<0.05)。观察组的便血消失时间、大便次数恢复正常时间、腹泻消失时间及腹痛消失时间短于对照组(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、高迁移率族蛋白B1(HMGB1)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、D-乳酸(D-LA)、二胺氧化酶(DAO)水平低于对照组,白细胞介素-10(IL-10)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平高于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的中国炎症性肠病生活质量问卷(IBDQOL)评分高于对照组(P<0.05)。结论益生菌联合美沙拉嗪治疗轻中度溃疡性结肠炎可改善临床症状,调节炎性因子水平,减轻氧化应激反应,改善肠黏膜屏障功能,提高疗效。Objective To explore the clinical effect of probiotics combined with mesalazine in the treatment of mild to moderate ulcerative colitis.Methods A total of 98 patients with mild to moderate ulcerative colitis admitted in our hospital from March 2022 to March 2023 were selected as the research objects.According to different treatment schemes,the patients were divided into control group and observation group,with 49 cases in each group.The control group was treated with mesalazine,and the observation group was treated with probiotics on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the scores of modified Mayo and Ulcerative Colitis Endoscopic Index of Severity(UCEIS)in the observation group were lower than those in the control group(P<0.05).The hematochezia disappearance time,normal stool frequency time,diarrhea disappearance time and abdominal pain disappearance time in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),high mobility group box 1 protein(HMGB1),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),D-lactic acid(D-LA)and diamine oxidase(DAO)in the observation group were lower than those in the control group,and the levels of interleukin-10(IL-10),superoxide dismutase(SOD)and catalase(CAT)were higher than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the Inflammatory Bowel Disease Quality of Life(IBDQOL)score of the observation group was higher than that of the control group(P<0.05).Conclusion Probiotics combined with mesalazine in the treatment of mild to moderate ulcerative colitis can improve clinical symptoms,regulate the levels of inflammatory factors,reduce oxidative stress,ameliorate intestinal mucosal barrier function and improve curative effect.

关 键 词：益生菌 美沙拉嗪 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]