氨磺必利联合利培酮治疗男性精神分裂症的疗效及不良反应分析  

Analysis of the curative effect and adverse reactions of amisulpride combined with risperidone in the treatment of male schizophrenia

作　　者：邵红霞[1] SHAO Hong-xia(Inner Mongolia Autonomous Region Mental Health Center,Hohhot 010010,China)

机构地区：[1]内蒙古自治区精神卫生中心,010010

出　　处：《中国现代药物应用》2025年第7期114-116,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨氨磺必利联合利培酮治疗男性精神分裂症的疗效及不良反应。方法100例男性精神分裂症患者为观察对象,以治疗模式差异分为观察组(50例)和对照组(50例)。观察组实行氨磺必利联合利培酮治疗,对照组实行利培酮治疗。对比两组治疗前后阳性和阴性症状量表(PANSS)评分、认知功能及临床疗效、不良反应发生率。结果治疗后,两组PANSS评分均低于治疗前,且观察组PANSS评分(52.71±5.71)分低于对照组的(60.94±6.56)分(P<0.05)。治疗后,两组连线测试、工作记忆、操作速度测试完成时间均短于治疗前,且观察组连线测试、工作记忆、操作速度测试完成时间分别为(38.42±2.18)、(10.54±1.27)、(33.96±3.49)min,均短于对照组的(42.24±2.56)、(12.66±1.73)、(38.81±3.87)min(P<0.05)。观察组治疗总有效率(96.00%)高于对照组(84.00%)(P<0.05)。观察组不良反应发生率与对照组对比,差异无统计学意义(P>0.05)。结论针对男性精神分裂症患者,在利培酮基础上联合氨磺必利治疗,可有效改善患者的临床症状,恢复患者的认知功能,提升临床疗效,且治疗安全性高,具有临床实践价值。Objective To explore the curative effect and adverse reactions of amisulpride combined with risperidone in the treatment of male schizophrenia.Methods 100 male patients with schizophrenia as observation subjects were divided into observation group(50 cases)and control group(50 cases)based on differences in treatment modes.The observation group was treated with amisulpride combined with risperidone,while the control group was treated with risperidone.The positive and negative symptom scale(PANSS)score and cognitive function before and after treatment,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,PANSS score in both groups was lower than that before treatment,and the observation group had a lower PANSS score of(52.71±5.71)points than(60.94±6.56)points in the control group(P<0.05).After treatment,the completion time of connection test,working memory,and operation speed test were shorter than those before treatment in both groups;the completion time of connection test,working memory,and operation speed test were(38.42±2.18),(10.54±1.27)and(33.96±3.49)min,which were shorter than(42.24±2.56),(12.66±1.73)and(38.81±3.87)min in the control group(P<0.05).The total effective rate of the observation group(96.00%)was higher than that of the control group(84.00%)(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion For male patients with schizophrenia,the combination of amisulpride and ziprasidone can effectively improve the clinical symptoms,restore cognitive function,enhance clinical efficacy,and have high treatment safety.It has clinical practical value.

关 键 词：氨磺必利 利培酮 男性精神分裂症 疗效 不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]