肿瘤治疗相关性口腔黏膜炎的发病机制和诊疗进展  

Progress in cancer therapy-related oral mucositis pathogenesis,diagnosis,and treatment

作　　者：胡凤林(综述) 吴国琳(审校)[1] Fenglin Hu;Guolin Wu(Department of Traditional Chinese Medicine,The First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属第一医院中医科,杭州市310000

出　　处：《中国肿瘤临床》2025年第5期248-252,共5页Chinese Journal of Clinical Oncology

基　　金：国家中医药综合改革示范区科技共建重点项目(编号:GZY-KJS-ZJ-2025-088);浙江省口腔黏膜病诊治中医药传承创新团队项目(编号:浙卫发[2023]31号)资助。

摘　　要：口腔黏膜炎(oral mucositis,OM)是肿瘤治疗的一种常见并发症,严重影响患者的生存质量。本文对肿瘤治疗相关性OM进行综述,探究肿瘤治疗相关性OM的病理生理机制,讨论了基本口腔护理、营养补充剂、冷冻疗法、光生物调节治疗、药物等OM相关的预防和治疗策略。虽然单独应用一种治疗方案可能也有一定的临床效果,但是在条件允许的情况下,采取预防与治疗相结合、多种治疗方式协同应用的方式,可以降低肿瘤治疗相关性OM的发生,促进OM的愈合,降低严重并发症的风险,提高患者生存质量。Oral mucositis(OM)is a prevalent and debilitating cancer therapy-related side effect that significantly impairs the quality of life of patients with cancer.In this article,we review anticancer treatment-induced OM,elucidate the underlying pathophysiological mechanisms,and discuss various preventive and therapeutic strategies,including basic oral care,nutritional supplements,cryotherapy,photobiomodulation therapy,and pharmacological interventions.While single modality treatments might yield certain clinical benefits,an integrated approach,combining prophylactic measures with multimodal therapies,could more effectively reduce OM incidence and severity,promote mucosal healing,minimize the risk of serious complications,and enhance patient outcomes.

关 键 词：肿瘤 口腔黏膜炎 预防治疗 

分 类 号：R781.5[医药卫生—口腔医学]