氧化锆种植体的表面修饰及其对骨整合的影响  

Surface modification of zirconia implants to promote bone integration

作　　者：余杰 刘劲松 Yu Jie;Liu Jinsong(Dept.of General Dentistry,Institute of Stomatology,Affiliated Hospital of Stomatology,Wenzhou Medical University,Wenzhou 325027,China;Dept.of Prosthodontics,Institute of Stomatology,Affiliated Hospital of Stomatology,Wen‐zhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学口腔医学院·附属口腔医院综合科,温州325027 [2]温州医科大学口腔医学院·附属口腔医院修复科,温州325027

出　　处：《国际口腔医学杂志》2025年第3期281-295,共15页International Journal of Stomatology

基　　金：国家自然科学基金(80220039)。

摘　　要：氧化锆种植体因其颜色类似天然牙齿,美学效果优良且具有适当的机械性能以及理想的生物相容性,可以减少种植体周围的炎症反应,成为替代钛种植体的可能选择。然而,与钛相比,未经处理的氧化锆表面具有生物惰性,导致其骨整合有限。由于表面特性在蛋白质的吸附、黏附、增殖和成骨相关细胞的分化中起着至关重要的作用,因此许多表面修饰被用于增强氧化锆的表面生物活性。本文综述了氧化锆种植体的各种表面修饰及其对骨整合的影响,并总结了几种表面改性方法的优缺点。Zirconia implants are considered as promising alternatives to titanium implants because of their tooth-like color that can simulate the appearance of natural teeth,appropriate mechanical properties,and biocompatibility,which re‐duce peri-implant inflammatory reactions.However,an untreated zirconia surface is bio-inert,which results in limited os‐seointegration compared with titanium.Considering that surface characteristics play an essential role in the adsorption of protein,adhesion,proliferation,and differentiation of osteogenesis-related cells,numerous surface modifications are ap‐plied to enhance the surface bioactivity of zirconia.In this review,various surface modifications of zirconia implants and their effects on osseointegration were comprehensively summarized.Meanwhile,the advantages and disadvantages of se-veral surface modifications were discussed.

关 键 词：表面改性 骨整合 氧化锆 种植体 

分 类 号：R783.1[医药卫生—口腔医学]